Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role...
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| Veröffentlicht in: | Microbes and infection 2017-03, Vol.19 (3), p.204-209 |
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| container_title | Microbes and infection |
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| creator | Friedrich, Dirk Fecher, Roger A. Rupp, Jan Deepe, George S. |
| description | Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response. |
| doi_str_mv | 10.1016/j.micinf.2016.10.008 |
| format | Article |
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The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. 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The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. 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| fulltext | fulltext |
| identifier | ISSN: 1286-4579 |
| ispartof | Microbes and infection, 2017-03, Vol.19 (3), p.204-209 |
| issn | 1286-4579 1769-714X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6863052 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Disease Models, Animal Fungal immunity Fungi - growth & development Fungi - immunology Fungi - pathogenicity HIF-1 Humans Hypoxia Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunity, Innate Mycoses - immunology Mycoses - pathology SREBP |
| title | Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity |
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