Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role...

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Veröffentlicht in:	Microbes and infection 2017-03, Vol.19 (3), p.204-209
Hauptverfasser:	Friedrich, Dirk, Fecher, Roger A., Rupp, Jan, Deepe, George S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Fungal immunity Fungi - growth & development Fungi - immunology Fungi - pathogenicity HIF-1 Humans Hypoxia Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunity, Innate Mycoses - immunology Mycoses - pathology SREBP
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Beschreibung
Zusammenfassung:	Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2016.10.008