Quantitative Phosphoproteomics Reveals System-Wide Phosphorylation Network Altered by Spry in Mouse Mammary Stromal Fibroblasts

Understanding the fundamental role of the stroma in normal development and cancer progression has been an emerging focus in recent years. The receptor tyrosine kinase (RTK) signaling pathway has been reported playing critical roles in regulating the normal and cancer microenvironment, but the underl...

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Veröffentlicht in:	International journal of molecular sciences 2019-10, Vol.20 (21), p.5400
Hauptverfasser:	Shi, Tiezhu, Yao, Linli, Han, Ying, Hao, Piliang, Lu, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Cell adhesion & migration Chromatography, Liquid Epidermal growth factor Female Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Kinases Localization Mammary gland Mammary glands Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mass spectrometry Medical prognosis Membrane Proteins - metabolism Metastasis Mice Microenvironments Ontology Phosphoproteins - metabolism Phosphorylation Protein expression Protein Interaction Maps Protein-tyrosine kinase receptors Proteins Proteomics - methods Roles Scientific imaging Signal Transduction Stroma Tandem Mass Spectrometry Tyrosine Vascular endothelial growth factor
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