microRNA‑mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K‑Akt signaling in osteoarthritis

Hyperplastic synovial fibroblasts (SFs) serve a critical role in the pathogenesis of knee osteoarthritis (OA); however, the molecular mechanism involved in OA during synovial tissue hyperproliferation remains unclear. Growth arrest-specific gene 1 (GAS1), a cell growth repressor gene, was found to b...

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Veröffentlicht in:	Experimental and therapeutic medicine 2019-12, Vol.18 (6), p.4273-4286
Hauptverfasser:	Dong, Chuan, Wang, Xinli, Li, Nan, Zhang, Kailiang, Wang, Xiaoyan, Zhang, Haomeng, Wang, Haipeng, Wang, Bo, An, Ming, Ma, Baoan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Arthritis Cancer Cell cycle Cell growth Cytokines Fibroblasts Gene expression Genes Health aspects Hyperplasia Inflammation Interleukins Joint surgery MicroRNA MicroRNAs Novels Osteoarthritis Pathogenesis Polymerase chain reaction Scientific equipment industry Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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