Role of High-Mobility Group Box-1 in Liver Pathogenesis

High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location. While intracellular HMGB1 is important for DNA structur...

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Veröffentlicht in:	International journal of molecular sciences 2019-10, Vol.20 (21), p.5314
Hauptverfasser:	Khambu, Bilon, Yan, Shengmin, Huda, Nazmul, Yin, Xiao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Animals Apoptosis Autophagy Cell activation Cellular stress response Cellular structure Cytosol Damage patterns Deoxyribonucleic acid DNA DNA methylation DNA structure DNA-binding protein Fatty liver Fibrosis Gene expression Glycosylation HMGB1 protein HMGB1 Protein - metabolism Humans Immune response Inflammation Liver Liver - metabolism Liver - pathology Liver diseases Liver Diseases - metabolism Liver Diseases - pathology Localization Mobility Phagocytosis Phosphorylation Proteins Receptor for Advanced Glycation End Products - metabolism Receptor mechanisms Review Signal Transduction Toll-like receptors Toll-Like Receptors - metabolism Tumorigenesis
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