Environmental Factors in Romanian and Belgian Patients with Inflammatory Bowel Disease – a Retrospective Comparative Study
Background:Several environmental factors have been associated with onset of inflammatory bowel diseases (IBD): smoking, hygiene, microorganisms, oral contraceptive pills (OCPs), non-steroid anti-inflammatory drugs, antibiotics, appendectomy, diet, breastfeeding, vitamin D, stress and ambient air pol...
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| Veröffentlicht in: | Mædica 2019-09, Vol.14 (3), p.233-239 |
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| creator | PREDA, Carmen Monica MANUC, Teodora ISTRATESCU, Doina LOUIS, Edouard BAICUS, Cristian SANDRA, Irina DICULESCU, Mircea REENAERS, Catherine KEMSEKE, Catherine van NITESCU, Maria TIERANU, Cristian SANDU, Corina Georgiana OPREA-CALIN, Gabriela TUGUI, Letitia VIZIRU, Siyana CIORA, Cosmin-Alexandru GHEORGHE, Liliana-Simona MANUC, Mircea |
| description | Background:Several environmental factors have been associated with onset of inflammatory bowel diseases (IBD): smoking, hygiene, microorganisms, oral contraceptive pills (OCPs), non-steroid anti-inflammatory drugs, antibiotics, appendectomy, diet, breastfeeding, vitamin D, stress and ambient air pollution. The aim of this study was to investigate the prevalence of these factors in a Romanian and Belgian population with IBD. Material and methods:A total of 129 patients with an IBD diagnosis (76 from Romania and 53 from Belgium) participated in an interview and were asked to fill in a questionnaire regarding environmental factors before and after the onset of IBD; 35 Romanian and 21 Belgian healthy individuals constituted the control group. Results:A total of 40 patients with ulcerative colitis (UC) and 89 with Crohn's disease (CD) were included. Gender distribution was 43% males and 57% females. They had a median age of 42 years (range between 19-74 years), a median disease duration of eight years and 79% were in clinical remission. Both Romanian and Belgian IBD patients reported an increased antibiotic consumption before IBD onset compared to controls: 58% vs 10% (p |
| doi_str_mv | 10.26574/maedica.2019.14.3.233 |
| format | Article |
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The aim of this study was to investigate the prevalence of these factors in a Romanian and Belgian population with IBD. Material and methods:A total of 129 patients with an IBD diagnosis (76 from Romania and 53 from Belgium) participated in an interview and were asked to fill in a questionnaire regarding environmental factors before and after the onset of IBD; 35 Romanian and 21 Belgian healthy individuals constituted the control group. Results:A total of 40 patients with ulcerative colitis (UC) and 89 with Crohn's disease (CD) were included. Gender distribution was 43% males and 57% females. They had a median age of 42 years (range between 19-74 years), a median disease duration of eight years and 79% were in clinical remission. Both Romanian and Belgian IBD patients reported an increased antibiotic consumption before IBD onset compared to controls: 58% vs 10% (p<0.001) and 51% vs 5% (p<0.001), respectively. Belgian IBD patients declared significantly more frequent OCP use (53% vs 9%, p <0.001), they were breastfed in a lower proportion (49% vs 76%, p <0.001) and had experienced a higher level of psychosocial stress (p<0.001). Conclusion:Antibiotic consumption before IBD onset may play a pivotal role in IBD development in both Romanian and Belgian populations. In Belgian patients, OCP consumption, a higher level of psychosocial stress and lack of breastfeeding may also be involved.</description><identifier>ISSN: 1841-9038</identifier><identifier>ISSN: 2069-6116</identifier><identifier>EISSN: 2069-6116</identifier><identifier>DOI: 10.26574/maedica.2019.14.3.233</identifier><identifier>PMID: 31798738</identifier><language>eng</language><publisher>Magister and Empire</publisher><subject>Belgian patients ; environmental factors ; Gastroenterology & hepatology ; Gastroentérologie & hépatologie ; Human health sciences ; IBD ; Original Paper ; retrospective comparative study ; Romanian patients ; Sciences de la santé humaine</subject><ispartof>Mædica, 2019-09, Vol.14 (3), p.233-239</ispartof><rights>2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861727/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861727/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>PREDA, Carmen Monica</creatorcontrib><creatorcontrib>MANUC, Teodora</creatorcontrib><creatorcontrib>ISTRATESCU, Doina</creatorcontrib><creatorcontrib>LOUIS, Edouard</creatorcontrib><creatorcontrib>BAICUS, Cristian</creatorcontrib><creatorcontrib>SANDRA, Irina</creatorcontrib><creatorcontrib>DICULESCU, Mircea</creatorcontrib><creatorcontrib>REENAERS, Catherine</creatorcontrib><creatorcontrib>KEMSEKE, Catherine van</creatorcontrib><creatorcontrib>NITESCU, Maria</creatorcontrib><creatorcontrib>TIERANU, Cristian</creatorcontrib><creatorcontrib>SANDU, Corina Georgiana</creatorcontrib><creatorcontrib>OPREA-CALIN, Gabriela</creatorcontrib><creatorcontrib>TUGUI, Letitia</creatorcontrib><creatorcontrib>VIZIRU, Siyana</creatorcontrib><creatorcontrib>CIORA, Cosmin-Alexandru</creatorcontrib><creatorcontrib>GHEORGHE, Liliana-Simona</creatorcontrib><creatorcontrib>MANUC, Mircea</creatorcontrib><title>Environmental Factors in Romanian and Belgian Patients with Inflammatory Bowel Disease – a Retrospective Comparative Study</title><title>Mædica</title><description>Background:Several environmental factors have been associated with onset of inflammatory bowel diseases (IBD): smoking, hygiene, microorganisms, oral contraceptive pills (OCPs), non-steroid anti-inflammatory drugs, antibiotics, appendectomy, diet, breastfeeding, vitamin D, stress and ambient air pollution. The aim of this study was to investigate the prevalence of these factors in a Romanian and Belgian population with IBD. Material and methods:A total of 129 patients with an IBD diagnosis (76 from Romania and 53 from Belgium) participated in an interview and were asked to fill in a questionnaire regarding environmental factors before and after the onset of IBD; 35 Romanian and 21 Belgian healthy individuals constituted the control group. Results:A total of 40 patients with ulcerative colitis (UC) and 89 with Crohn's disease (CD) were included. Gender distribution was 43% males and 57% females. They had a median age of 42 years (range between 19-74 years), a median disease duration of eight years and 79% were in clinical remission. Both Romanian and Belgian IBD patients reported an increased antibiotic consumption before IBD onset compared to controls: 58% vs 10% (p<0.001) and 51% vs 5% (p<0.001), respectively. Belgian IBD patients declared significantly more frequent OCP use (53% vs 9%, p <0.001), they were breastfed in a lower proportion (49% vs 76%, p <0.001) and had experienced a higher level of psychosocial stress (p<0.001). Conclusion:Antibiotic consumption before IBD onset may play a pivotal role in IBD development in both Romanian and Belgian populations. In Belgian patients, OCP consumption, a higher level of psychosocial stress and lack of breastfeeding may also be involved.</description><subject>Belgian patients</subject><subject>environmental factors</subject><subject>Gastroenterology & hepatology</subject><subject>Gastroentérologie & hépatologie</subject><subject>Human health sciences</subject><subject>IBD</subject><subject>Original Paper</subject><subject>retrospective comparative study</subject><subject>Romanian patients</subject><subject>Sciences de la santé humaine</subject><issn>1841-9038</issn><issn>2069-6116</issn><issn>2069-6116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkd9qFDEYxYModql9BcmlNzPNn5kkcyPYtdVCQal6HTKZb7aRTLImM1sWvPAdfEOfxHR3EcxNDuT8TpLvIPSakpqJVjaXk4HBWVMzQruaNjWvGefP0IoR0VWCUvEcrahqaNURrs7QRc7fSVktU1KQl-iMU9kpydUK_bwOO5dimCDMxuMbY-eYMnYB38fJBGcCNmHAV-A3T_qzmV1xZvzo5gd8G0ZvpskUZI-v4iN4_N5lMBnwn1-_scH3MKeYt2BntwO8jtPWJHPQX-Zl2L9CL0bjM1yc9nP07eb66_pjdffpw-363V1lGZO8Yr0Q0I5C9UPfS8bACqoIcE7UqMZ-oF0vJJODsAyIUiMMvIxD9W2BOsUIP0dvj7nbpZ9gsOUHyXi9TW4yaa-jcfr_k-Ae9CbutFCCluQSwI8B3sEGdEy90zt2AA968RttrO5BMyaUZo1suSjUm9O1Kf5YIM96ctmC9yZAXLJmnFEheUtYsYqj1ZZ55QTjv8dRog-d61Pn-qlzTRvNC8_5Xwgso10</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>PREDA, Carmen Monica</creator><creator>MANUC, Teodora</creator><creator>ISTRATESCU, Doina</creator><creator>LOUIS, Edouard</creator><creator>BAICUS, Cristian</creator><creator>SANDRA, Irina</creator><creator>DICULESCU, Mircea</creator><creator>REENAERS, Catherine</creator><creator>KEMSEKE, Catherine van</creator><creator>NITESCU, Maria</creator><creator>TIERANU, Cristian</creator><creator>SANDU, Corina Georgiana</creator><creator>OPREA-CALIN, Gabriela</creator><creator>TUGUI, Letitia</creator><creator>VIZIRU, Siyana</creator><creator>CIORA, Cosmin-Alexandru</creator><creator>GHEORGHE, Liliana-Simona</creator><creator>MANUC, Mircea</creator><general>Magister and Empire</general><general>Tarus Media</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Environmental Factors in Romanian and Belgian Patients with Inflammatory Bowel Disease – a Retrospective Comparative Study</title><author>PREDA, Carmen Monica ; MANUC, Teodora ; ISTRATESCU, Doina ; LOUIS, Edouard ; BAICUS, Cristian ; SANDRA, Irina ; DICULESCU, Mircea ; REENAERS, Catherine ; KEMSEKE, Catherine van ; NITESCU, Maria ; TIERANU, Cristian ; SANDU, Corina Georgiana ; OPREA-CALIN, Gabriela ; TUGUI, Letitia ; VIZIRU, Siyana ; CIORA, Cosmin-Alexandru ; GHEORGHE, Liliana-Simona ; MANUC, Mircea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2273-2b66e5f68bdbb722ec6180e3308f8fbd19b6727d6c2e088fed32338b5e5f98203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Belgian patients</topic><topic>environmental factors</topic><topic>Gastroenterology & hepatology</topic><topic>Gastroentérologie & hépatologie</topic><topic>Human health sciences</topic><topic>IBD</topic><topic>Original Paper</topic><topic>retrospective comparative study</topic><topic>Romanian patients</topic><topic>Sciences de la santé humaine</topic><toplevel>online_resources</toplevel><creatorcontrib>PREDA, Carmen Monica</creatorcontrib><creatorcontrib>MANUC, Teodora</creatorcontrib><creatorcontrib>ISTRATESCU, Doina</creatorcontrib><creatorcontrib>LOUIS, Edouard</creatorcontrib><creatorcontrib>BAICUS, Cristian</creatorcontrib><creatorcontrib>SANDRA, Irina</creatorcontrib><creatorcontrib>DICULESCU, Mircea</creatorcontrib><creatorcontrib>REENAERS, Catherine</creatorcontrib><creatorcontrib>KEMSEKE, Catherine van</creatorcontrib><creatorcontrib>NITESCU, Maria</creatorcontrib><creatorcontrib>TIERANU, Cristian</creatorcontrib><creatorcontrib>SANDU, Corina Georgiana</creatorcontrib><creatorcontrib>OPREA-CALIN, Gabriela</creatorcontrib><creatorcontrib>TUGUI, Letitia</creatorcontrib><creatorcontrib>VIZIRU, Siyana</creatorcontrib><creatorcontrib>CIORA, Cosmin-Alexandru</creatorcontrib><creatorcontrib>GHEORGHE, Liliana-Simona</creatorcontrib><creatorcontrib>MANUC, Mircea</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mædica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PREDA, Carmen Monica</au><au>MANUC, Teodora</au><au>ISTRATESCU, Doina</au><au>LOUIS, Edouard</au><au>BAICUS, Cristian</au><au>SANDRA, Irina</au><au>DICULESCU, Mircea</au><au>REENAERS, Catherine</au><au>KEMSEKE, Catherine van</au><au>NITESCU, Maria</au><au>TIERANU, Cristian</au><au>SANDU, Corina Georgiana</au><au>OPREA-CALIN, Gabriela</au><au>TUGUI, Letitia</au><au>VIZIRU, Siyana</au><au>CIORA, Cosmin-Alexandru</au><au>GHEORGHE, Liliana-Simona</au><au>MANUC, Mircea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental Factors in Romanian and Belgian Patients with Inflammatory Bowel Disease – a Retrospective Comparative Study</atitle><jtitle>Mædica</jtitle><date>2019-09-01</date><risdate>2019</risdate><volume>14</volume><issue>3</issue><spage>233</spage><epage>239</epage><pages>233-239</pages><issn>1841-9038</issn><issn>2069-6116</issn><eissn>2069-6116</eissn><abstract>Background:Several environmental factors have been associated with onset of inflammatory bowel diseases (IBD): smoking, hygiene, microorganisms, oral contraceptive pills (OCPs), non-steroid anti-inflammatory drugs, antibiotics, appendectomy, diet, breastfeeding, vitamin D, stress and ambient air pollution. The aim of this study was to investigate the prevalence of these factors in a Romanian and Belgian population with IBD. Material and methods:A total of 129 patients with an IBD diagnosis (76 from Romania and 53 from Belgium) participated in an interview and were asked to fill in a questionnaire regarding environmental factors before and after the onset of IBD; 35 Romanian and 21 Belgian healthy individuals constituted the control group. Results:A total of 40 patients with ulcerative colitis (UC) and 89 with Crohn's disease (CD) were included. Gender distribution was 43% males and 57% females. They had a median age of 42 years (range between 19-74 years), a median disease duration of eight years and 79% were in clinical remission. Both Romanian and Belgian IBD patients reported an increased antibiotic consumption before IBD onset compared to controls: 58% vs 10% (p<0.001) and 51% vs 5% (p<0.001), respectively. Belgian IBD patients declared significantly more frequent OCP use (53% vs 9%, p <0.001), they were breastfed in a lower proportion (49% vs 76%, p <0.001) and had experienced a higher level of psychosocial stress (p<0.001). Conclusion:Antibiotic consumption before IBD onset may play a pivotal role in IBD development in both Romanian and Belgian populations. In Belgian patients, OCP consumption, a higher level of psychosocial stress and lack of breastfeeding may also be involved.</abstract><pub>Magister and Empire</pub><pmid>31798738</pmid><doi>10.26574/maedica.2019.14.3.233</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Belgian patients environmental factors Gastroenterology & hepatology Gastroentérologie & hépatologie Human health sciences IBD Original Paper retrospective comparative study Romanian patients Sciences de la santé humaine |
| title | Environmental Factors in Romanian and Belgian Patients with Inflammatory Bowel Disease – a Retrospective Comparative Study |
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