Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics

Many multidomain proteins contain disordered linkers that regulate interdomain contacts, and thus the effective concentrations that govern intramolecular reactions. Effective concentrations are rarely measured experimentally, and therefore little is known about how they relate to linker architecture...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-11, Vol.116 (46), p.23124-23131
Hauptverfasser:	Sørensen, Charlotte S., Kjaergaard, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Biological Sciences Biophysical Phenomena Biosensors Compaction Fluorescence Hydrophobicity Intrinsically Disordered Proteins - metabolism Physics PNAS Plus Polymer physics Polymers Protein Domains Proteins Residues
Online-Zugang:	Volltext
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