A small molecule protects mitochondrial integrity by inhibiting mTOR activity

Apoptosis activation by cytochrome c release from mitochondria to cytosol is a normal cellular response to mitochondrial damage. Using cellular apoptosis assay, we have found small-molecule apoptosis inhibitors that protect cells from mitochondrial damage. Previously, we reported the discovery of a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-11, Vol.116 (46), p.23332-23338
Hauptverfasser:	Cao, Ran, Li, Li, Ying, Zhengxin, Cao, Zichen, Ma, Yongfen, Mao, Xiaoxu, Li, Jiaojiao, Qi, Xiangbing, Zhang, Zhiyuan, Wang, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Bcl-2-Like Protein 11 - metabolism Biological Sciences Blood-brain barrier Brain Cell death Compound A Cytochrome Cytochrome c Cytochromes Cytosol Damage Dopamine receptors Drug Evaluation, Preclinical Electron transport Integrity Intravenous administration Ischemia Male Mitochondria Mitochondria - drug effects Movement disorders Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Parkinson's disease Phagocytosis Pharmacokinetics Rapamycin Rats, Sprague-Dawley Reperfusion Succinate dehydrogenase Test animals TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors
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