The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition
Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations...
Gespeichert in:
| Veröffentlicht in: | Chest 2019-10, Vol.156 (4), p.685-695 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 695 |
|---|---|
| container_issue | 4 |
| container_start_page | 685 |
| container_title | Chest |
| container_volume | 156 |
| creator | Kim, Victor Regan, Elizabeth Han, MeiLan K. Jones, Paul W. Curtis, Jeffrey L. Silverman, Edwin K. Criner, Gerard J. Crapo, James D. Silverman, Edwin K. Regan, Elizabeth A. Beaty, Terri Begum, Ferdouse Castaldi, Peter J. Cho, Michael DeMeo, Dawn L. Halper-Stromberg, Eitan Hansel, Nadia N. Hardin, Megan E. Hetmanski, Jacqueline Hokanson, John E. Laird, Nan Lange, Christoph McDonald, Merry-Lynn Parker, Margaret M. Qiao, Dandi Santorico, Stephanie Silverman, Edwin K. Won, Sungho Charbonnier, Jean-Paul Han, MeiLan K. Hoffman, Eric A. Jacobson, Francine L. Judy, Philip F. Kluiber, Alex Lynch, David A. Newell, John D. Ross, James C. San Jose Estepar, Raul Stoel, Berend C. van Ginneken, Bram van Rikxoort, Eva Washko, George Jensen, Robert Everett, Douglas Moore, Camille Strand, Matt Hughes, John Pratte, Katherine Young, Kendra A. Martinez, Carlos H. Pernicano, Perry G. Hanania, Nicola Alapat, Philip Bandi, Venkata Boriek, Aladin Guy, Elizabeth Nachiappan, Arun Parulekar, Amit D’Souza, Belinda Pearson, Gregory D.N. Rozenshtein, Anna MacIntyre, Neil McAdams, H. Page Washington, Lacey Wise, Robert Horton, Karen Putcha, Nirupama Fischer, Hans Rossiter, Harry Stringer, William Sharafkhaneh, Amir Lan, Charlie Bell, Brian Flenaugh, Eric L. Westney, Gloria Pace, David Dass, Chandra D’Alonzo, Gilbert Desai, Parag Kelsen, Steven Satti, Aditi Shenoy, Kartik Steiner, Robert M. Vega-Sanchez, Maria Elena Dransfield, Mark Nath, Hrudaya Oates, Gabriela Ramsdell, Joe Yen, Andrew Comellas, Alejandro P. Newell, John Kazerooni, Ella Billings, Joanne Begnaud, Abbie Allen, Tadashi Sciurba, Frank Bon, Jessica Chandra, Divay Weissfeld, Joel Ruiz, Mario E. |
| description | Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown.
We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates.
There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not.
The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB. |
| doi_str_mv | 10.1016/j.chest.2019.03.041 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859248</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0012369219308815</els_id><sourcerecordid>2229239166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-abf0c08feaa41adf70658fc26bed8df7ca52a041c3ec2fcdcea3bc6a60c80a653</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtRCILoVfgIR85JLgj8RNDiCxaSlIRS1QxNGaeCeNV9l4a3sr9sbf4IbEP-Gn8EtwuqXAhdNoZt689zSPkMec5Zxx9WyZmx5DzAXjdc5kzgp-h8x4LXkmy0LeJTPGuMikqsUeeRDCkqWe1-o-2ZOcFQd1Wc7I9_Me6YeY02N0_gJ_fvka6HsMa-shOr-l7zZJwrpxBOuRHmJnRzv11HW06b0braHzVEyfxoG-hS2dI4Uf3-YYI3p65nFhTaK6Pjg9O6RHn8Ggb2FiCbRxqzUkDP1kY09jMtMMEEJi_aP1kNzrYAj46Kbuk4-vjs6b19nJ6fGb5uVJZoqyjhm0HTOs6hCg4LDoDpgqq84I1eKiSq2BUkB6kpFoRGcWBkG2RoFipmKgSrlPXux415t2hWk_Rg-DXnu7Ar_VDqz-dzPaXl-4K62qshZFlQie3hB4dzk9Tq9sMDgMMKLbBC2EqIWsuVIJKndQ410IHrtbGc70FK9e6ut49RSvZlIn5-nqyd8Ob29-55kAz3cATH-6suh1MBZHk0LwaKJeOPtfgV8N6r5u</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2229239166</pqid></control><display><type>article</type><title>The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kim, Victor ; Regan, Elizabeth ; Han, MeiLan K. ; Jones, Paul W. ; Curtis, Jeffrey L. ; Silverman, Edwin K. ; Criner, Gerard J. ; Crapo, James D. ; Silverman, Edwin K. ; Regan, Elizabeth A. ; Beaty, Terri ; Begum, Ferdouse ; Castaldi, Peter J. ; Cho, Michael ; DeMeo, Dawn L. ; Halper-Stromberg, Eitan ; Hansel, Nadia N. ; Hardin, Megan E. ; Hetmanski, Jacqueline ; Hokanson, John E. ; Laird, Nan ; Lange, Christoph ; McDonald, Merry-Lynn ; Parker, Margaret M. ; Qiao, Dandi ; Santorico, Stephanie ; Silverman, Edwin K. ; Won, Sungho ; Charbonnier, Jean-Paul ; Han, MeiLan K. ; Hoffman, Eric A. ; Jacobson, Francine L. ; Judy, Philip F. ; Kluiber, Alex ; Lynch, David A. ; Newell, John D. ; Ross, James C. ; San Jose Estepar, Raul ; Stoel, Berend C. ; van Ginneken, Bram ; van Rikxoort, Eva ; Washko, George ; Jensen, Robert ; Everett, Douglas ; Moore, Camille ; Strand, Matt ; Hughes, John ; Pratte, Katherine ; Young, Kendra A. ; Martinez, Carlos H. ; Pernicano, Perry G. ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Boriek, Aladin ; Guy, Elizabeth ; Nachiappan, Arun ; Parulekar, Amit ; D’Souza, Belinda ; Pearson, Gregory D.N. ; Rozenshtein, Anna ; MacIntyre, Neil ; McAdams, H. Page ; Washington, Lacey ; Wise, Robert ; Horton, Karen ; Putcha, Nirupama ; Fischer, Hans ; Rossiter, Harry ; Stringer, William ; Sharafkhaneh, Amir ; Lan, Charlie ; Bell, Brian ; Flenaugh, Eric L. ; Westney, Gloria ; Pace, David ; Dass, Chandra ; D’Alonzo, Gilbert ; Desai, Parag ; Kelsen, Steven ; Satti, Aditi ; Shenoy, Kartik ; Steiner, Robert M. ; Vega-Sanchez, Maria Elena ; Dransfield, Mark ; Nath, Hrudaya ; Oates, Gabriela ; Ramsdell, Joe ; Yen, Andrew ; Comellas, Alejandro P. ; Newell, John ; Kazerooni, Ella ; Billings, Joanne ; Begnaud, Abbie ; Allen, Tadashi ; Sciurba, Frank ; Bon, Jessica ; Chandra, Divay ; Weissfeld, Joel ; Ruiz, Mario E.</creator><creatorcontrib>Kim, Victor ; Regan, Elizabeth ; Han, MeiLan K. ; Jones, Paul W. ; Curtis, Jeffrey L. ; Silverman, Edwin K. ; Criner, Gerard J. ; Crapo, James D. ; Silverman, Edwin K. ; Regan, Elizabeth A. ; Beaty, Terri ; Begum, Ferdouse ; Castaldi, Peter J. ; Cho, Michael ; DeMeo, Dawn L. ; Halper-Stromberg, Eitan ; Hansel, Nadia N. ; Hardin, Megan E. ; Hetmanski, Jacqueline ; Hokanson, John E. ; Laird, Nan ; Lange, Christoph ; McDonald, Merry-Lynn ; Parker, Margaret M. ; Qiao, Dandi ; Santorico, Stephanie ; Silverman, Edwin K. ; Won, Sungho ; Charbonnier, Jean-Paul ; Han, MeiLan K. ; Hoffman, Eric A. ; Jacobson, Francine L. ; Judy, Philip F. ; Kluiber, Alex ; Lynch, David A. ; Newell, John D. ; Ross, James C. ; San Jose Estepar, Raul ; Stoel, Berend C. ; van Ginneken, Bram ; van Rikxoort, Eva ; Washko, George ; Jensen, Robert ; Everett, Douglas ; Moore, Camille ; Strand, Matt ; Hughes, John ; Pratte, Katherine ; Young, Kendra A. ; Martinez, Carlos H. ; Pernicano, Perry G. ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Boriek, Aladin ; Guy, Elizabeth ; Nachiappan, Arun ; Parulekar, Amit ; D’Souza, Belinda ; Pearson, Gregory D.N. ; Rozenshtein, Anna ; MacIntyre, Neil ; McAdams, H. Page ; Washington, Lacey ; Wise, Robert ; Horton, Karen ; Putcha, Nirupama ; Fischer, Hans ; Rossiter, Harry ; Stringer, William ; Sharafkhaneh, Amir ; Lan, Charlie ; Bell, Brian ; Flenaugh, Eric L. ; Westney, Gloria ; Pace, David ; Dass, Chandra ; D’Alonzo, Gilbert ; Desai, Parag ; Kelsen, Steven ; Satti, Aditi ; Shenoy, Kartik ; Steiner, Robert M. ; Vega-Sanchez, Maria Elena ; Dransfield, Mark ; Nath, Hrudaya ; Oates, Gabriela ; Ramsdell, Joe ; Yen, Andrew ; Comellas, Alejandro P. ; Newell, John ; Kazerooni, Ella ; Billings, Joanne ; Begnaud, Abbie ; Allen, Tadashi ; Sciurba, Frank ; Bon, Jessica ; Chandra, Divay ; Weissfeld, Joel ; Ruiz, Mario E. ; COPDGene Investigators</creatorcontrib><description>Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown.
We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates.
There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not.
The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1016/j.chest.2019.03.041</identifier><identifier>PMID: 31047955</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Bronchitis, Chronic - complications ; Bronchitis, Chronic - diagnosis ; chronic bronchitis ; COPD ; cough ; Diagnostic Self Evaluation ; Disease Progression ; exacerbations ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Pulmonary Disease, Chronic Obstructive - etiology ; Severity of Illness Index</subject><ispartof>Chest, 2019-10, Vol.156 (4), p.685-695</ispartof><rights>2019 American College of Chest Physicians</rights><rights>Copyright © 2019 American College of Chest Physicians. All rights reserved.</rights><rights>2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. 2019 American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-abf0c08feaa41adf70658fc26bed8df7ca52a041c3ec2fcdcea3bc6a60c80a653</citedby><cites>FETCH-LOGICAL-c459t-abf0c08feaa41adf70658fc26bed8df7ca52a041c3ec2fcdcea3bc6a60c80a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31047955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Victor</creatorcontrib><creatorcontrib>Regan, Elizabeth</creatorcontrib><creatorcontrib>Han, MeiLan K.</creatorcontrib><creatorcontrib>Jones, Paul W.</creatorcontrib><creatorcontrib>Curtis, Jeffrey L.</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Criner, Gerard J.</creatorcontrib><creatorcontrib>Crapo, James D.</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Regan, Elizabeth A.</creatorcontrib><creatorcontrib>Beaty, Terri</creatorcontrib><creatorcontrib>Begum, Ferdouse</creatorcontrib><creatorcontrib>Castaldi, Peter J.</creatorcontrib><creatorcontrib>Cho, Michael</creatorcontrib><creatorcontrib>DeMeo, Dawn L.</creatorcontrib><creatorcontrib>Halper-Stromberg, Eitan</creatorcontrib><creatorcontrib>Hansel, Nadia N.</creatorcontrib><creatorcontrib>Hardin, Megan E.</creatorcontrib><creatorcontrib>Hetmanski, Jacqueline</creatorcontrib><creatorcontrib>Hokanson, John E.</creatorcontrib><creatorcontrib>Laird, Nan</creatorcontrib><creatorcontrib>Lange, Christoph</creatorcontrib><creatorcontrib>McDonald, Merry-Lynn</creatorcontrib><creatorcontrib>Parker, Margaret M.</creatorcontrib><creatorcontrib>Qiao, Dandi</creatorcontrib><creatorcontrib>Santorico, Stephanie</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Won, Sungho</creatorcontrib><creatorcontrib>Charbonnier, Jean-Paul</creatorcontrib><creatorcontrib>Han, MeiLan K.</creatorcontrib><creatorcontrib>Hoffman, Eric A.</creatorcontrib><creatorcontrib>Jacobson, Francine L.</creatorcontrib><creatorcontrib>Judy, Philip F.</creatorcontrib><creatorcontrib>Kluiber, Alex</creatorcontrib><creatorcontrib>Lynch, David A.</creatorcontrib><creatorcontrib>Newell, John D.</creatorcontrib><creatorcontrib>Ross, James C.</creatorcontrib><creatorcontrib>San Jose Estepar, Raul</creatorcontrib><creatorcontrib>Stoel, Berend C.</creatorcontrib><creatorcontrib>van Ginneken, Bram</creatorcontrib><creatorcontrib>van Rikxoort, Eva</creatorcontrib><creatorcontrib>Washko, George</creatorcontrib><creatorcontrib>Jensen, Robert</creatorcontrib><creatorcontrib>Everett, Douglas</creatorcontrib><creatorcontrib>Moore, Camille</creatorcontrib><creatorcontrib>Strand, Matt</creatorcontrib><creatorcontrib>Hughes, John</creatorcontrib><creatorcontrib>Pratte, Katherine</creatorcontrib><creatorcontrib>Young, Kendra A.</creatorcontrib><creatorcontrib>Martinez, Carlos H.</creatorcontrib><creatorcontrib>Pernicano, Perry G.</creatorcontrib><creatorcontrib>Hanania, Nicola</creatorcontrib><creatorcontrib>Alapat, Philip</creatorcontrib><creatorcontrib>Bandi, Venkata</creatorcontrib><creatorcontrib>Boriek, Aladin</creatorcontrib><creatorcontrib>Guy, Elizabeth</creatorcontrib><creatorcontrib>Nachiappan, Arun</creatorcontrib><creatorcontrib>Parulekar, Amit</creatorcontrib><creatorcontrib>D’Souza, Belinda</creatorcontrib><creatorcontrib>Pearson, Gregory D.N.</creatorcontrib><creatorcontrib>Rozenshtein, Anna</creatorcontrib><creatorcontrib>MacIntyre, Neil</creatorcontrib><creatorcontrib>McAdams, H. Page</creatorcontrib><creatorcontrib>Washington, Lacey</creatorcontrib><creatorcontrib>Wise, Robert</creatorcontrib><creatorcontrib>Horton, Karen</creatorcontrib><creatorcontrib>Putcha, Nirupama</creatorcontrib><creatorcontrib>Fischer, Hans</creatorcontrib><creatorcontrib>Rossiter, Harry</creatorcontrib><creatorcontrib>Stringer, William</creatorcontrib><creatorcontrib>Sharafkhaneh, Amir</creatorcontrib><creatorcontrib>Lan, Charlie</creatorcontrib><creatorcontrib>Bell, Brian</creatorcontrib><creatorcontrib>Flenaugh, Eric L.</creatorcontrib><creatorcontrib>Westney, Gloria</creatorcontrib><creatorcontrib>Pace, David</creatorcontrib><creatorcontrib>Dass, Chandra</creatorcontrib><creatorcontrib>D’Alonzo, Gilbert</creatorcontrib><creatorcontrib>Desai, Parag</creatorcontrib><creatorcontrib>Kelsen, Steven</creatorcontrib><creatorcontrib>Satti, Aditi</creatorcontrib><creatorcontrib>Shenoy, Kartik</creatorcontrib><creatorcontrib>Steiner, Robert M.</creatorcontrib><creatorcontrib>Vega-Sanchez, Maria Elena</creatorcontrib><creatorcontrib>Dransfield, Mark</creatorcontrib><creatorcontrib>Nath, Hrudaya</creatorcontrib><creatorcontrib>Oates, Gabriela</creatorcontrib><creatorcontrib>Ramsdell, Joe</creatorcontrib><creatorcontrib>Yen, Andrew</creatorcontrib><creatorcontrib>Comellas, Alejandro P.</creatorcontrib><creatorcontrib>Newell, John</creatorcontrib><creatorcontrib>Kazerooni, Ella</creatorcontrib><creatorcontrib>Billings, Joanne</creatorcontrib><creatorcontrib>Begnaud, Abbie</creatorcontrib><creatorcontrib>Allen, Tadashi</creatorcontrib><creatorcontrib>Sciurba, Frank</creatorcontrib><creatorcontrib>Bon, Jessica</creatorcontrib><creatorcontrib>Chandra, Divay</creatorcontrib><creatorcontrib>Weissfeld, Joel</creatorcontrib><creatorcontrib>Ruiz, Mario E.</creatorcontrib><creatorcontrib>COPDGene Investigators</creatorcontrib><title>The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition</title><title>Chest</title><addtitle>Chest</addtitle><description>Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown.
We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates.
There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not.
The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.</description><subject>Aged</subject><subject>Bronchitis, Chronic - complications</subject><subject>Bronchitis, Chronic - diagnosis</subject><subject>chronic bronchitis</subject><subject>COPD</subject><subject>cough</subject><subject>Diagnostic Self Evaluation</subject><subject>Disease Progression</subject><subject>exacerbations</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Severity of Illness Index</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCILoVfgIR85JLgj8RNDiCxaSlIRS1QxNGaeCeNV9l4a3sr9sbf4IbEP-Gn8EtwuqXAhdNoZt689zSPkMec5Zxx9WyZmx5DzAXjdc5kzgp-h8x4LXkmy0LeJTPGuMikqsUeeRDCkqWe1-o-2ZOcFQd1Wc7I9_Me6YeY02N0_gJ_fvka6HsMa-shOr-l7zZJwrpxBOuRHmJnRzv11HW06b0braHzVEyfxoG-hS2dI4Uf3-YYI3p65nFhTaK6Pjg9O6RHn8Ggb2FiCbRxqzUkDP1kY09jMtMMEEJi_aP1kNzrYAj46Kbuk4-vjs6b19nJ6fGb5uVJZoqyjhm0HTOs6hCg4LDoDpgqq84I1eKiSq2BUkB6kpFoRGcWBkG2RoFipmKgSrlPXux415t2hWk_Rg-DXnu7Ar_VDqz-dzPaXl-4K62qshZFlQie3hB4dzk9Tq9sMDgMMKLbBC2EqIWsuVIJKndQ410IHrtbGc70FK9e6ut49RSvZlIn5-nqyd8Ob29-55kAz3cATH-6suh1MBZHk0LwaKJeOPtfgV8N6r5u</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Kim, Victor</creator><creator>Regan, Elizabeth</creator><creator>Han, MeiLan K.</creator><creator>Jones, Paul W.</creator><creator>Curtis, Jeffrey L.</creator><creator>Silverman, Edwin K.</creator><creator>Criner, Gerard J.</creator><creator>Crapo, James D.</creator><creator>Silverman, Edwin K.</creator><creator>Regan, Elizabeth A.</creator><creator>Beaty, Terri</creator><creator>Begum, Ferdouse</creator><creator>Castaldi, Peter J.</creator><creator>Cho, Michael</creator><creator>DeMeo, Dawn L.</creator><creator>Halper-Stromberg, Eitan</creator><creator>Hansel, Nadia N.</creator><creator>Hardin, Megan E.</creator><creator>Hetmanski, Jacqueline</creator><creator>Hokanson, John E.</creator><creator>Laird, Nan</creator><creator>Lange, Christoph</creator><creator>McDonald, Merry-Lynn</creator><creator>Parker, Margaret M.</creator><creator>Qiao, Dandi</creator><creator>Santorico, Stephanie</creator><creator>Silverman, Edwin K.</creator><creator>Won, Sungho</creator><creator>Charbonnier, Jean-Paul</creator><creator>Han, MeiLan K.</creator><creator>Hoffman, Eric A.</creator><creator>Jacobson, Francine L.</creator><creator>Judy, Philip F.</creator><creator>Kluiber, Alex</creator><creator>Lynch, David A.</creator><creator>Newell, John D.</creator><creator>Ross, James C.</creator><creator>San Jose Estepar, Raul</creator><creator>Stoel, Berend C.</creator><creator>van Ginneken, Bram</creator><creator>van Rikxoort, Eva</creator><creator>Washko, George</creator><creator>Jensen, Robert</creator><creator>Everett, Douglas</creator><creator>Moore, Camille</creator><creator>Strand, Matt</creator><creator>Hughes, John</creator><creator>Pratte, Katherine</creator><creator>Young, Kendra A.</creator><creator>Martinez, Carlos H.</creator><creator>Pernicano, Perry G.</creator><creator>Hanania, Nicola</creator><creator>Alapat, Philip</creator><creator>Bandi, Venkata</creator><creator>Boriek, Aladin</creator><creator>Guy, Elizabeth</creator><creator>Nachiappan, Arun</creator><creator>Parulekar, Amit</creator><creator>D’Souza, Belinda</creator><creator>Pearson, Gregory D.N.</creator><creator>Rozenshtein, Anna</creator><creator>MacIntyre, Neil</creator><creator>McAdams, H. Page</creator><creator>Washington, Lacey</creator><creator>Wise, Robert</creator><creator>Horton, Karen</creator><creator>Putcha, Nirupama</creator><creator>Fischer, Hans</creator><creator>Rossiter, Harry</creator><creator>Stringer, William</creator><creator>Sharafkhaneh, Amir</creator><creator>Lan, Charlie</creator><creator>Bell, Brian</creator><creator>Flenaugh, Eric L.</creator><creator>Westney, Gloria</creator><creator>Pace, David</creator><creator>Dass, Chandra</creator><creator>D’Alonzo, Gilbert</creator><creator>Desai, Parag</creator><creator>Kelsen, Steven</creator><creator>Satti, Aditi</creator><creator>Shenoy, Kartik</creator><creator>Steiner, Robert M.</creator><creator>Vega-Sanchez, Maria Elena</creator><creator>Dransfield, Mark</creator><creator>Nath, Hrudaya</creator><creator>Oates, Gabriela</creator><creator>Ramsdell, Joe</creator><creator>Yen, Andrew</creator><creator>Comellas, Alejandro P.</creator><creator>Newell, John</creator><creator>Kazerooni, Ella</creator><creator>Billings, Joanne</creator><creator>Begnaud, Abbie</creator><creator>Allen, Tadashi</creator><creator>Sciurba, Frank</creator><creator>Bon, Jessica</creator><creator>Chandra, Divay</creator><creator>Weissfeld, Joel</creator><creator>Ruiz, Mario E.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191001</creationdate><title>The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition</title><author>Kim, Victor ; Regan, Elizabeth ; Han, MeiLan K. ; Jones, Paul W. ; Curtis, Jeffrey L. ; Silverman, Edwin K. ; Criner, Gerard J. ; Crapo, James D. ; Silverman, Edwin K. ; Regan, Elizabeth A. ; Beaty, Terri ; Begum, Ferdouse ; Castaldi, Peter J. ; Cho, Michael ; DeMeo, Dawn L. ; Halper-Stromberg, Eitan ; Hansel, Nadia N. ; Hardin, Megan E. ; Hetmanski, Jacqueline ; Hokanson, John E. ; Laird, Nan ; Lange, Christoph ; McDonald, Merry-Lynn ; Parker, Margaret M. ; Qiao, Dandi ; Santorico, Stephanie ; Silverman, Edwin K. ; Won, Sungho ; Charbonnier, Jean-Paul ; Han, MeiLan K. ; Hoffman, Eric A. ; Jacobson, Francine L. ; Judy, Philip F. ; Kluiber, Alex ; Lynch, David A. ; Newell, John D. ; Ross, James C. ; San Jose Estepar, Raul ; Stoel, Berend C. ; van Ginneken, Bram ; van Rikxoort, Eva ; Washko, George ; Jensen, Robert ; Everett, Douglas ; Moore, Camille ; Strand, Matt ; Hughes, John ; Pratte, Katherine ; Young, Kendra A. ; Martinez, Carlos H. ; Pernicano, Perry G. ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Boriek, Aladin ; Guy, Elizabeth ; Nachiappan, Arun ; Parulekar, Amit ; D’Souza, Belinda ; Pearson, Gregory D.N. ; Rozenshtein, Anna ; MacIntyre, Neil ; McAdams, H. Page ; Washington, Lacey ; Wise, Robert ; Horton, Karen ; Putcha, Nirupama ; Fischer, Hans ; Rossiter, Harry ; Stringer, William ; Sharafkhaneh, Amir ; Lan, Charlie ; Bell, Brian ; Flenaugh, Eric L. ; Westney, Gloria ; Pace, David ; Dass, Chandra ; D’Alonzo, Gilbert ; Desai, Parag ; Kelsen, Steven ; Satti, Aditi ; Shenoy, Kartik ; Steiner, Robert M. ; Vega-Sanchez, Maria Elena ; Dransfield, Mark ; Nath, Hrudaya ; Oates, Gabriela ; Ramsdell, Joe ; Yen, Andrew ; Comellas, Alejandro P. ; Newell, John ; Kazerooni, Ella ; Billings, Joanne ; Begnaud, Abbie ; Allen, Tadashi ; Sciurba, Frank ; Bon, Jessica ; Chandra, Divay ; Weissfeld, Joel ; Ruiz, Mario E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-abf0c08feaa41adf70658fc26bed8df7ca52a041c3ec2fcdcea3bc6a60c80a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Bronchitis, Chronic - complications</topic><topic>Bronchitis, Chronic - diagnosis</topic><topic>chronic bronchitis</topic><topic>COPD</topic><topic>cough</topic><topic>Diagnostic Self Evaluation</topic><topic>Disease Progression</topic><topic>exacerbations</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Pulmonary Disease, Chronic Obstructive - etiology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Victor</creatorcontrib><creatorcontrib>Regan, Elizabeth</creatorcontrib><creatorcontrib>Han, MeiLan K.</creatorcontrib><creatorcontrib>Jones, Paul W.</creatorcontrib><creatorcontrib>Curtis, Jeffrey L.</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Criner, Gerard J.</creatorcontrib><creatorcontrib>Crapo, James D.</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Regan, Elizabeth A.</creatorcontrib><creatorcontrib>Beaty, Terri</creatorcontrib><creatorcontrib>Begum, Ferdouse</creatorcontrib><creatorcontrib>Castaldi, Peter J.</creatorcontrib><creatorcontrib>Cho, Michael</creatorcontrib><creatorcontrib>DeMeo, Dawn L.</creatorcontrib><creatorcontrib>Halper-Stromberg, Eitan</creatorcontrib><creatorcontrib>Hansel, Nadia N.</creatorcontrib><creatorcontrib>Hardin, Megan E.</creatorcontrib><creatorcontrib>Hetmanski, Jacqueline</creatorcontrib><creatorcontrib>Hokanson, John E.</creatorcontrib><creatorcontrib>Laird, Nan</creatorcontrib><creatorcontrib>Lange, Christoph</creatorcontrib><creatorcontrib>McDonald, Merry-Lynn</creatorcontrib><creatorcontrib>Parker, Margaret M.</creatorcontrib><creatorcontrib>Qiao, Dandi</creatorcontrib><creatorcontrib>Santorico, Stephanie</creatorcontrib><creatorcontrib>Silverman, Edwin K.</creatorcontrib><creatorcontrib>Won, Sungho</creatorcontrib><creatorcontrib>Charbonnier, Jean-Paul</creatorcontrib><creatorcontrib>Han, MeiLan K.</creatorcontrib><creatorcontrib>Hoffman, Eric A.</creatorcontrib><creatorcontrib>Jacobson, Francine L.</creatorcontrib><creatorcontrib>Judy, Philip F.</creatorcontrib><creatorcontrib>Kluiber, Alex</creatorcontrib><creatorcontrib>Lynch, David A.</creatorcontrib><creatorcontrib>Newell, John D.</creatorcontrib><creatorcontrib>Ross, James C.</creatorcontrib><creatorcontrib>San Jose Estepar, Raul</creatorcontrib><creatorcontrib>Stoel, Berend C.</creatorcontrib><creatorcontrib>van Ginneken, Bram</creatorcontrib><creatorcontrib>van Rikxoort, Eva</creatorcontrib><creatorcontrib>Washko, George</creatorcontrib><creatorcontrib>Jensen, Robert</creatorcontrib><creatorcontrib>Everett, Douglas</creatorcontrib><creatorcontrib>Moore, Camille</creatorcontrib><creatorcontrib>Strand, Matt</creatorcontrib><creatorcontrib>Hughes, John</creatorcontrib><creatorcontrib>Pratte, Katherine</creatorcontrib><creatorcontrib>Young, Kendra A.</creatorcontrib><creatorcontrib>Martinez, Carlos H.</creatorcontrib><creatorcontrib>Pernicano, Perry G.</creatorcontrib><creatorcontrib>Hanania, Nicola</creatorcontrib><creatorcontrib>Alapat, Philip</creatorcontrib><creatorcontrib>Bandi, Venkata</creatorcontrib><creatorcontrib>Boriek, Aladin</creatorcontrib><creatorcontrib>Guy, Elizabeth</creatorcontrib><creatorcontrib>Nachiappan, Arun</creatorcontrib><creatorcontrib>Parulekar, Amit</creatorcontrib><creatorcontrib>D’Souza, Belinda</creatorcontrib><creatorcontrib>Pearson, Gregory D.N.</creatorcontrib><creatorcontrib>Rozenshtein, Anna</creatorcontrib><creatorcontrib>MacIntyre, Neil</creatorcontrib><creatorcontrib>McAdams, H. Page</creatorcontrib><creatorcontrib>Washington, Lacey</creatorcontrib><creatorcontrib>Wise, Robert</creatorcontrib><creatorcontrib>Horton, Karen</creatorcontrib><creatorcontrib>Putcha, Nirupama</creatorcontrib><creatorcontrib>Fischer, Hans</creatorcontrib><creatorcontrib>Rossiter, Harry</creatorcontrib><creatorcontrib>Stringer, William</creatorcontrib><creatorcontrib>Sharafkhaneh, Amir</creatorcontrib><creatorcontrib>Lan, Charlie</creatorcontrib><creatorcontrib>Bell, Brian</creatorcontrib><creatorcontrib>Flenaugh, Eric L.</creatorcontrib><creatorcontrib>Westney, Gloria</creatorcontrib><creatorcontrib>Pace, David</creatorcontrib><creatorcontrib>Dass, Chandra</creatorcontrib><creatorcontrib>D’Alonzo, Gilbert</creatorcontrib><creatorcontrib>Desai, Parag</creatorcontrib><creatorcontrib>Kelsen, Steven</creatorcontrib><creatorcontrib>Satti, Aditi</creatorcontrib><creatorcontrib>Shenoy, Kartik</creatorcontrib><creatorcontrib>Steiner, Robert M.</creatorcontrib><creatorcontrib>Vega-Sanchez, Maria Elena</creatorcontrib><creatorcontrib>Dransfield, Mark</creatorcontrib><creatorcontrib>Nath, Hrudaya</creatorcontrib><creatorcontrib>Oates, Gabriela</creatorcontrib><creatorcontrib>Ramsdell, Joe</creatorcontrib><creatorcontrib>Yen, Andrew</creatorcontrib><creatorcontrib>Comellas, Alejandro P.</creatorcontrib><creatorcontrib>Newell, John</creatorcontrib><creatorcontrib>Kazerooni, Ella</creatorcontrib><creatorcontrib>Billings, Joanne</creatorcontrib><creatorcontrib>Begnaud, Abbie</creatorcontrib><creatorcontrib>Allen, Tadashi</creatorcontrib><creatorcontrib>Sciurba, Frank</creatorcontrib><creatorcontrib>Bon, Jessica</creatorcontrib><creatorcontrib>Chandra, Divay</creatorcontrib><creatorcontrib>Weissfeld, Joel</creatorcontrib><creatorcontrib>Ruiz, Mario E.</creatorcontrib><creatorcontrib>COPDGene Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Victor</au><au>Regan, Elizabeth</au><au>Han, MeiLan K.</au><au>Jones, Paul W.</au><au>Curtis, Jeffrey L.</au><au>Silverman, Edwin K.</au><au>Criner, Gerard J.</au><au>Crapo, James D.</au><au>Silverman, Edwin K.</au><au>Regan, Elizabeth A.</au><au>Beaty, Terri</au><au>Begum, Ferdouse</au><au>Castaldi, Peter J.</au><au>Cho, Michael</au><au>DeMeo, Dawn L.</au><au>Halper-Stromberg, Eitan</au><au>Hansel, Nadia N.</au><au>Hardin, Megan E.</au><au>Hetmanski, Jacqueline</au><au>Hokanson, John E.</au><au>Laird, Nan</au><au>Lange, Christoph</au><au>McDonald, Merry-Lynn</au><au>Parker, Margaret M.</au><au>Qiao, Dandi</au><au>Santorico, Stephanie</au><au>Silverman, Edwin K.</au><au>Won, Sungho</au><au>Charbonnier, Jean-Paul</au><au>Han, MeiLan K.</au><au>Hoffman, Eric A.</au><au>Jacobson, Francine L.</au><au>Judy, Philip F.</au><au>Kluiber, Alex</au><au>Lynch, David A.</au><au>Newell, John D.</au><au>Ross, James C.</au><au>San Jose Estepar, Raul</au><au>Stoel, Berend C.</au><au>van Ginneken, Bram</au><au>van Rikxoort, Eva</au><au>Washko, George</au><au>Jensen, Robert</au><au>Everett, Douglas</au><au>Moore, Camille</au><au>Strand, Matt</au><au>Hughes, John</au><au>Pratte, Katherine</au><au>Young, Kendra A.</au><au>Martinez, Carlos H.</au><au>Pernicano, Perry G.</au><au>Hanania, Nicola</au><au>Alapat, Philip</au><au>Bandi, Venkata</au><au>Boriek, Aladin</au><au>Guy, Elizabeth</au><au>Nachiappan, Arun</au><au>Parulekar, Amit</au><au>D’Souza, Belinda</au><au>Pearson, Gregory D.N.</au><au>Rozenshtein, Anna</au><au>MacIntyre, Neil</au><au>McAdams, H. Page</au><au>Washington, Lacey</au><au>Wise, Robert</au><au>Horton, Karen</au><au>Putcha, Nirupama</au><au>Fischer, Hans</au><au>Rossiter, Harry</au><au>Stringer, William</au><au>Sharafkhaneh, Amir</au><au>Lan, Charlie</au><au>Bell, Brian</au><au>Flenaugh, Eric L.</au><au>Westney, Gloria</au><au>Pace, David</au><au>Dass, Chandra</au><au>D’Alonzo, Gilbert</au><au>Desai, Parag</au><au>Kelsen, Steven</au><au>Satti, Aditi</au><au>Shenoy, Kartik</au><au>Steiner, Robert M.</au><au>Vega-Sanchez, Maria Elena</au><au>Dransfield, Mark</au><au>Nath, Hrudaya</au><au>Oates, Gabriela</au><au>Ramsdell, Joe</au><au>Yen, Andrew</au><au>Comellas, Alejandro P.</au><au>Newell, John</au><au>Kazerooni, Ella</au><au>Billings, Joanne</au><au>Begnaud, Abbie</au><au>Allen, Tadashi</au><au>Sciurba, Frank</au><au>Bon, Jessica</au><au>Chandra, Divay</au><au>Weissfeld, Joel</au><au>Ruiz, Mario E.</au><aucorp>COPDGene Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>156</volume><issue>4</issue><spage>685</spage><epage>695</epage><pages>685-695</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown.
We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates.
There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not.
The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31047955</pmid><doi>10.1016/j.chest.2019.03.041</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 2019-10, Vol.156 (4), p.685-695 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859248 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Bronchitis, Chronic - complications Bronchitis, Chronic - diagnosis chronic bronchitis COPD cough Diagnostic Self Evaluation Disease Progression exacerbations Female Humans Male Middle Aged Prognosis Pulmonary Disease, Chronic Obstructive - etiology Severity of Illness Index |
| title | The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T01%3A32%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20St.%20George%E2%80%99s%20Respiratory%20Questionnaire%20Definition%20of%20Chronic%20Bronchitis%20May%20Be%20a%C2%A0Better%20Predictor%20of%20COPD%20Exacerbations%20Compared%20With%20the%20Classic%20Definition&rft.jtitle=Chest&rft.au=Kim,%20Victor&rft.aucorp=COPDGene%20Investigators&rft.date=2019-10-01&rft.volume=156&rft.issue=4&rft.spage=685&rft.epage=695&rft.pages=685-695&rft.issn=0012-3692&rft.eissn=1931-3543&rft_id=info:doi/10.1016/j.chest.2019.03.041&rft_dat=%3Cproquest_pubme%3E2229239166%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2229239166&rft_id=info:pmid/31047955&rft_els_id=S0012369219308815&rfr_iscdi=true |