Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

Our aim was to investigate the patterns and trajectories of white matter (WM) diffusion abnormalities in microtubule-associated protein tau (MAPT) mutations carriers. We studied 22 MAPT mutation carriers (12 asymptomatic, 10 symptomatic) and 20 noncarriers from 8 families, who underwent diffusion te...

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Veröffentlicht in:	Neurobiology of aging 2019-11, Vol.83, p.54-62
Hauptverfasser:	Chen, Qin, Boeve, Bradley F., Schwarz, Christopher G., Reid, Robert, Tosakulwong, Nirubol, Lesnick, Timothy G., Bove, Jessica, Brannelly, Patrick, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickerson, Bradford C., Dickinson, Susan, Faber, Kelley, Fields, Julie, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah, Gavrilova, Ralitza H., Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiung, Ging-Yuek R., Huey, Edward, Irwin, David J., Jack, Clifford R., Jones, David T., Jones, Lynne, Karydas, Anna M., Knopman, David S., Kornak, John, Kramer, Joel, Kremers, Walter, Kukull, Walter A., Lapid, Maria, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R.A., Manoochehri, Masood, McGinnis, Scott, Miller, Bruce L., Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana M., Rankin, Katherine P., Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John, Weintraub, Sandra, Wong, Bonnie, Boxer, Adam L., Rosen, Howie, Wszolek, Zbigniew, Kantarci, Kejal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Asymptomatic Diffusion Magnetic Resonance Imaging - methods Diffusion tensor image Diffusion Tensor Imaging - methods Disease Progression Female Frontotemporal dementia Frontotemporal Dementia - genetics Frontotemporal Dementia - pathology Gray Matter - pathology Heterozygote Humans Longitudinal Male MAPT Middle Aged Mutation - genetics Neurodegenerative Diseases - genetics Neuropsychological Tests tau Proteins - genetics White Matter - pathology
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