In Situ Modification of Tissue Stem and Progenitor Cell Genomes

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, w...

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Veröffentlicht in:	Cell reports (Cambridge) 2019-04, Vol.27 (4), p.1254-1264.e7
Hauptverfasser:	Goldstein, Jill M., Tabebordbar, Mohammadsharif, Zhu, Kexian, Wang, Leo D., Messemer, Kathleen A., Peacker, Bryan, Ashrafi Kakhki, Sara, Gonzalez-Celeiro, Meryem, Shwartz, Yulia, Cheng, Jason K.W., Xiao, Ru, Barungi, Trisha, Albright, Charles, Hsu, Ya-Chieh, Vandenberghe, Luk H., Wagers, Amy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AAV Animals Cell Differentiation Cell Movement Dependovirus - classification Dependovirus - genetics dermal Female gene modification Gene Transfer Techniques Genetic Therapy Genome hematopoietic Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Male mesenchymal Mice, Inbred C57BL Mice, Inbred mdx muscle progenitor satellite cell Satellite Cells, Skeletal Muscle - cytology Satellite Cells, Skeletal Muscle - metabolism Skin - cytology Skin - metabolism stem cell
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