Infant Formula Feeding Increases Hepatic Cholesterol 7α Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets

During the postnatal feeding period, formula-fed infants have higher cholesterol synthesis rates and lower circulating cholesterol concentrations than their breastfed counterparts. Although this disparity has been attributed to the uniformly low dietary cholesterol content of typical infant formulas...

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Veröffentlicht in:	The Journal of nutrition 2018-05, Vol.148 (5), p.702-711
Hauptverfasser:	Mercer, Kelly E, Bhattacharyya, Sudeepa, Diaz-Rubio, Maria Elena, Piccolo, Brian D, Pack, Lindsay M, Sharma, Neha, Chaudhury, Mousumi, Cleves, Mario A, Chintapalli, Sree V, Shankar, Kartik, Ronis, Martin JJ, Yeruva, Laxmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn bile acid synthesis bile acids Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism blood serum bottle feeding breast feeding breastfeeding cholesterol Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism cholesterol 7-α hydroxylase cholesterol metabolism enterohepatic circulation enzymes etiology feces Feces - chemistry Female females fibroblasts Food and Nutrition gene expression Gene Expression Regulation, Enzymologic - drug effects genes Glycine max Infant Formula infant formulas intestines landraces Life Sciences liquid chromatography liver Liver - enzymology Male males mass spectrometry messenger RNA microbiome Milk Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions nutrition phenotype piglet feeding piglets protein synthesis Random Allocation Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction sow milk Swine transcription (genetics) Western blotting
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