N-cadherin stabilises neural identity by dampening anti-neural signals

A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use qua...

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Veröffentlicht in:	Development (Cambridge) 2019-11, Vol.146 (21)
Hauptverfasser:	Punovuori, Karolina, Migueles, Rosa P, Malaguti, Mattias, Blin, Guillaume, Macleod, Kenneth G, Carragher, Neil O, Pieters, Tim, van Roy, Frans, Stemmler, Marc P, Lowell, Sally
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - physiology Cadherins - physiology Cell Differentiation Cell Lineage Cell Nucleus - physiology Cells, Cultured Embryonic Stem Cells - cytology Fibroblast Growth Factors - physiology Germ Layers - physiology Mice Mice, Transgenic Neurons - cytology Pluripotent Stem Cells - cytology Stem Cells and Regeneration
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