Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1

IRE1α-mediated unconventional splicing of XBP1 is emerging as a biomarker in several disease states and is indicative of activation of the unfolded protein response sensor IRE1. Splicing of mRNA results in the translation of two distinct XBP1 protein isoforms (XBP1s and XBP1u) which, due to post-tra...

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Veröffentlicht in:	Biological procedures online 2019-11, Vol.21 (1), p.22-22, Article 22
Hauptverfasser:	Creedican, Stuart, Talty, Aaron, Fitzgerald, Stephen P, Samali, Afshin, Richardson, Ciarán, Gorman, Adrienne M, Martin, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherent cells Breast cancer Cancer Cancer therapies Clinical trials Inflammasomes Isoforms Kinases Laboratories Lysates Medical research Messenger RNA Methodology mRNA Paclitaxel Polymerase chain reaction Post-translation Protein arrays Protein folding Proteins Ribonuclease RNA Signal transduction Splicing Technology Transcription factors Translation (Genetics)
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