Immune cell trafficking to the islets during type 1 diabetes

Summary Inhibition of immune cell trafficking to the pancreatic islets during type 1 diabetes (T1D) has therapeutic potential, since targeting of T cell and B cell trafficking has been clinically effective in other autoimmune diseases. Trafficking to the islets is characterized by redundancy in adhe...

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Veröffentlicht in:	Clinical and experimental immunology 2019-12, Vol.198 (3), p.314-325
Hauptverfasser:	Sandor, A. M., Jacobelli, J., Friedman, R. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Animals Autoimmune diseases autoimmunity B-Lymphocytes - immunology Beta cells Cell Movement - immunology cell trafficking Chemokines Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Disease Progression Humans Immunology of Diabetes Society Review Series: Insights into Pathogenesis of Type 1 Diabetes Series Editors: F. Susan Wong and Timothy I. Tree Islets of Langerhans - immunology Lymphocytes Lymphocytes T Myeloid cells Myeloid Cells - immunology Pancreas Pathogens Review Signal Transduction - immunology T-Lymphocytes - immunology
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