Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
Summary The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous i...
Gespeichert in:
| Veröffentlicht in: | Immunology 2019-12, Vol.158 (4), p.267-280 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 280 |
|---|---|
| container_issue | 4 |
| container_start_page | 267 |
| container_title | Immunology |
| container_volume | 158 |
| creator | Soderholm, Amelia T. Pedicord, Virginia A. |
| description | Summary
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. IECs also respond to factors produced by immune cells, and these can regulate IEC barrier function, proliferation and differentiation, as well as influence the composition of the microbiota. The mechanisms involved in IEC–microbe–immune interactions, however, are not fully characterized. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.
Beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells. |
| doi_str_mv | 10.1111/imm.13117 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6856932</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2288712691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5097-7f44a5b02dbebcc2cf69b7fc3ded428ca5462b13c9b3a89a790ec48a6b5665903</originalsourceid><addsrcrecordid>eNp1kUtPxCAUhYnROONj4R8wTdzoosqj0OLCxBgfk2jc6JoApQ6mLWNpNfPvveOMEzWRDXD5OFzOQeiA4FMC48w3zSlhhOQbaEyY4CnlIt9EY4yJTGmB-QjtxPgKW4Y530YjRjiWlMkxepq0vYu9b3WduJnvp672sLSuruN5ovsEKokHpqu0dUmovgqNt10wPvQ60W2ZNIMNEW5BH0Pr-_ke2qp0Hd3-at5FzzfXT1d36f3j7eTq8j618Hye5lWWaW4wLY0z1lJbCWnyyrLSlRktrOaZoIYwKw3ThdS5xM5mhRaGC8ElZrvoYqk7G0zjSuvavtO1mnW-0d1cBe3V75PWT9VLeFei4EIyCgLHK4EuvA3gg2p8XPxdty4MUVFaFDmhQhJAj_6gr2HowDagGMkyiUm2oE6WFPgTY-eqdTMEq0VWCjxSX1kBe_iz-zX5HQ4AZ0vgw9du_r-Smjw8LCU_AS2wny0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2314490141</pqid></control><display><type>article</type><title>Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Soderholm, Amelia T. ; Pedicord, Virginia A.</creator><creatorcontrib>Soderholm, Amelia T. ; Pedicord, Virginia A.</creatorcontrib><description>Summary
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. IECs also respond to factors produced by immune cells, and these can regulate IEC barrier function, proliferation and differentiation, as well as influence the composition of the microbiota. The mechanisms involved in IEC–microbe–immune interactions, however, are not fully characterized. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.
Beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1111/imm.13117</identifier><identifier>PMID: 31509239</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adaptive Immunity ; Animals ; bacterial ; Barriers ; Cell Communication ; Cell interactions ; Cell proliferation ; Crosstalk ; epithelial cell ; Epithelial cells ; Epithelium ; gut ; Homeostasis ; Host-Pathogen Interactions ; Humans ; Immune system ; Immunity, Mucosal ; Inflammation ; Inflammation - immunology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Intestine ; Microbiota ; Microbiota - immunology ; Microorganisms ; Mucosal immunity ; mucosal immunology ; Receptors, Pattern Recognition - metabolism ; Review ; Tight Junctions - pathology</subject><ispartof>Immunology, 2019-12, Vol.158 (4), p.267-280</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5097-7f44a5b02dbebcc2cf69b7fc3ded428ca5462b13c9b3a89a790ec48a6b5665903</citedby><cites>FETCH-LOGICAL-c5097-7f44a5b02dbebcc2cf69b7fc3ded428ca5462b13c9b3a89a790ec48a6b5665903</cites><orcidid>0000-0001-9625-3122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856932/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856932/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,1414,1430,27907,27908,45557,45558,46392,46816,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31509239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soderholm, Amelia T.</creatorcontrib><creatorcontrib>Pedicord, Virginia A.</creatorcontrib><title>Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. IECs also respond to factors produced by immune cells, and these can regulate IEC barrier function, proliferation and differentiation, as well as influence the composition of the microbiota. The mechanisms involved in IEC–microbe–immune interactions, however, are not fully characterized. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.
Beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>bacterial</subject><subject>Barriers</subject><subject>Cell Communication</subject><subject>Cell interactions</subject><subject>Cell proliferation</subject><subject>Crosstalk</subject><subject>epithelial cell</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>gut</subject><subject>Homeostasis</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Mucosal</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestine</subject><subject>Microbiota</subject><subject>Microbiota - immunology</subject><subject>Microorganisms</subject><subject>Mucosal immunity</subject><subject>mucosal immunology</subject><subject>Receptors, Pattern Recognition - metabolism</subject><subject>Review</subject><subject>Tight Junctions - pathology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPxCAUhYnROONj4R8wTdzoosqj0OLCxBgfk2jc6JoApQ6mLWNpNfPvveOMEzWRDXD5OFzOQeiA4FMC48w3zSlhhOQbaEyY4CnlIt9EY4yJTGmB-QjtxPgKW4Y530YjRjiWlMkxepq0vYu9b3WduJnvp672sLSuruN5ovsEKokHpqu0dUmovgqNt10wPvQ60W2ZNIMNEW5BH0Pr-_ke2qp0Hd3-at5FzzfXT1d36f3j7eTq8j618Hye5lWWaW4wLY0z1lJbCWnyyrLSlRktrOaZoIYwKw3ThdS5xM5mhRaGC8ElZrvoYqk7G0zjSuvavtO1mnW-0d1cBe3V75PWT9VLeFei4EIyCgLHK4EuvA3gg2p8XPxdty4MUVFaFDmhQhJAj_6gr2HowDagGMkyiUm2oE6WFPgTY-eqdTMEq0VWCjxSX1kBe_iz-zX5HQ4AZ0vgw9du_r-Smjw8LCU_AS2wny0</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Soderholm, Amelia T.</creator><creator>Pedicord, Virginia A.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9625-3122</orcidid></search><sort><creationdate>201912</creationdate><title>Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity</title><author>Soderholm, Amelia T. ; Pedicord, Virginia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5097-7f44a5b02dbebcc2cf69b7fc3ded428ca5462b13c9b3a89a790ec48a6b5665903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adaptive Immunity</topic><topic>Animals</topic><topic>bacterial</topic><topic>Barriers</topic><topic>Cell Communication</topic><topic>Cell interactions</topic><topic>Cell proliferation</topic><topic>Crosstalk</topic><topic>epithelial cell</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>gut</topic><topic>Homeostasis</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity, Mucosal</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestine</topic><topic>Microbiota</topic><topic>Microbiota - immunology</topic><topic>Microorganisms</topic><topic>Mucosal immunity</topic><topic>mucosal immunology</topic><topic>Receptors, Pattern Recognition - metabolism</topic><topic>Review</topic><topic>Tight Junctions - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soderholm, Amelia T.</creatorcontrib><creatorcontrib>Pedicord, Virginia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soderholm, Amelia T.</au><au>Pedicord, Virginia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2019-12</date><risdate>2019</risdate><volume>158</volume><issue>4</issue><spage>267</spage><epage>280</epage><pages>267-280</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. IECs also respond to factors produced by immune cells, and these can regulate IEC barrier function, proliferation and differentiation, as well as influence the composition of the microbiota. The mechanisms involved in IEC–microbe–immune interactions, however, are not fully characterized. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.
Beyond acting as a physical barrier, the function of intestinal epithelial cells (IECs) in sensing and responding to microbial signals is increasingly appreciated and likely has numerous implications for the vast network of immune cells within and below the intestinal epithelium. In this review, we explore the ability of IECs to direct intestinal homeostasis by orchestrating communication between intestinal microbes and mucosal innate and adaptive immune cells during physiological and inflammatory conditions. We focus primarily on the most recent findings and call attention to the numerous remaining unknowns regarding the complex crosstalk between IECs, the microbiota and intestinal immune cells.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31509239</pmid><doi>10.1111/imm.13117</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9625-3122</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-2805 |
| ispartof | Immunology, 2019-12, Vol.158 (4), p.267-280 |
| issn | 0019-2805 1365-2567 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6856932 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adaptive Immunity Animals bacterial Barriers Cell Communication Cell interactions Cell proliferation Crosstalk epithelial cell Epithelial cells Epithelium gut Homeostasis Host-Pathogen Interactions Humans Immune system Immunity, Mucosal Inflammation Inflammation - immunology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestine Microbiota Microbiota - immunology Microorganisms Mucosal immunity mucosal immunology Receptors, Pattern Recognition - metabolism Review Tight Junctions - pathology |
| title | Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T08%3A22%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intestinal%20epithelial%20cells:%20at%20the%20interface%20of%20the%20microbiota%20and%20mucosal%20immunity&rft.jtitle=Immunology&rft.au=Soderholm,%20Amelia%20T.&rft.date=2019-12&rft.volume=158&rft.issue=4&rft.spage=267&rft.epage=280&rft.pages=267-280&rft.issn=0019-2805&rft.eissn=1365-2567&rft_id=info:doi/10.1111/imm.13117&rft_dat=%3Cproquest_pubme%3E2288712691%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2314490141&rft_id=info:pmid/31509239&rfr_iscdi=true |