Probiotic survival during a multi‐layered tablet development as tested in a dynamic, computer‐controlled in vitro model of the stomach and small intestine (TIM‐1)

The aim of the research was to develop a galenical formulation for the combination of the three probiotic strains Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3 and Bifidobacterium bifidum MF 20/5 that would lead to the presence of a high amount of viable cells in the small intestine,...

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Veröffentlicht in:	Letters in applied microbiology 2019-11, Vol.69 (5), p.325-332
Hauptverfasser:	Venema, K., Verhoeven, J., Verbruggen, S., Espinosa, L., Courau, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Aged Bifidobacterium Bifidobacterium - growth & development Bifidobacterium bifidum Bifidobacterium longum cell viability coatings Computer simulation Drug Compounding elderly Gastrointestinal system Gastrointestinal tract Geriatrics Humans Impact prediction Intestine Intestine, Small - microbiology Lactobacillus Lactobacillus - growth & development Lactobacillus gasseri Microbial Viability multi‐layered tablet Optimization Original probiotic Probiotics Probiotics - chemistry Small intestine Stomach Stomach - microbiology Survival Tablets - chemistry TIM‐1 Transit Yogurt
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