Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation

Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital Achilles heel in a pathogen of interest. Here, we report the...

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Veröffentlicht in:	Cell chemical biology 2019-09, Vol.26 (9), p.1274-1282.e4
Hauptverfasser:	McAuley, Scott, Huynh, Alan, Howells, Alison, Walpole, Chris, Maxwell, Anthony, Nodwell, Justin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology DNA Gyrase - drug effects DNA Gyrase - metabolism Drug Discovery - methods Microbial Sensitivity Tests Spores, Bacterial - drug effects Streptomyces - drug effects Streptomyces - metabolism Topoisomerase II Inhibitors - isolation & purification Topoisomerase II Inhibitors - metabolism Topoisomerase II Inhibitors - pharmacology
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