Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis
Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent with cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, patient...
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| Veröffentlicht in: | Journal of Cancer 2019-01, Vol.10 (24), p.6161-6169 |
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| creator | Li, Guangli Zhou, Zhijuan Yang, Wencong Yang, Hao Fan, Xiuwu Yin, Yuelan Luo, Liyun Zhang, Jinyou Wu, Niujian Liang, Zibin Ke, Jianting Chen, Jian |
| description | Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent with cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, patients diagnosed with AML between 1973 and 2015 were identified in the Surveillance, Epidemiology, and End Results database. Cumulative mortality by cause of death was calculated. To quantify the excessive cardiac-specific death compared with the general population, standardized mortality ratios (SMRs) were calculated. Multivariate Cox regression analyses were performed to identify risk factors associated with cardiac-specific death and AML-specific death. Results: A total of 64,679 AML patients were identified between 1973 and 2015; 68.48% of patients (44,292) received chemotherapy. Among all possible competing causes of death, AML was associated with the highest cumulative mortality. The AML patients who received chemotherapy showed excessive cardiac-specific mortality compared with the general population, with an SMR of 6.35 (95% CI: 5.89-6.82). Age, year of diagnosis, sex, and marital status were independently associated with patient prognosis. Conclusion: Cardiac-specific mortality in AML patients receiving chemotherapy is higher than that in the general population. |
| doi_str_mv | 10.7150/jca.36948 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6856578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2317961997</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-bed9e398ea8f655ce0a9bf8d389601bdb0014da891cca2991e9ba056c47c0c13</originalsourceid><addsrcrecordid>eNpd0c-O1SAUBnBiNM5knIVvQOJGEztCaSm4MDET_yU3cTN7ckpP53KFUoFq-gY-tuhMjMoGEn75cuAj5ClnVwPv2auThSshdacekHOuxNBoKbuHf53PyGXOJ1aX0O3QicfkTPBBtqqV5-THIS63TcEUqIU0ObBNXtG62VkaYirgXdkphKpo171sdUvBbgVp2NFHN1GP2xcMDugKxeFSMi0JoeBEv7typPaIIZYjJlj317SquG6-yrg0I-SqYAG_Z5efkEcz-IyX9_sFuXn_7ub6Y3P4_OHT9dtDY4VipRlx0ii0QlCz7HuLDPQ4q0koLRkfp5Ex3k2gNLcWWq056hFYL203WGa5uCBv7mLXbQw42TpxAm_W5AKk3URw5t-bxR3NbfxmpOplP6ga8Pw-IMWvG-ZigssWvYcF45ZNW_9WS671UOmz_-gpbqm-t6pe13oUE6yqF3fKpphzwvnPMJyZXw2b2rD53bD4CSVNmn4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2598378030</pqid></control><display><type>article</type><title>Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Li, Guangli ; Zhou, Zhijuan ; Yang, Wencong ; Yang, Hao ; Fan, Xiuwu ; Yin, Yuelan ; Luo, Liyun ; Zhang, Jinyou ; Wu, Niujian ; Liang, Zibin ; Ke, Jianting ; Chen, Jian</creator><creatorcontrib>Li, Guangli ; Zhou, Zhijuan ; Yang, Wencong ; Yang, Hao ; Fan, Xiuwu ; Yin, Yuelan ; Luo, Liyun ; Zhang, Jinyou ; Wu, Niujian ; Liang, Zibin ; Ke, Jianting ; Chen, Jian</creatorcontrib><description>Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent with cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, patients diagnosed with AML between 1973 and 2015 were identified in the Surveillance, Epidemiology, and End Results database. Cumulative mortality by cause of death was calculated. To quantify the excessive cardiac-specific death compared with the general population, standardized mortality ratios (SMRs) were calculated. Multivariate Cox regression analyses were performed to identify risk factors associated with cardiac-specific death and AML-specific death. Results: A total of 64,679 AML patients were identified between 1973 and 2015; 68.48% of patients (44,292) received chemotherapy. Among all possible competing causes of death, AML was associated with the highest cumulative mortality. The AML patients who received chemotherapy showed excessive cardiac-specific mortality compared with the general population, with an SMR of 6.35 (95% CI: 5.89-6.82). Age, year of diagnosis, sex, and marital status were independently associated with patient prognosis. Conclusion: Cardiac-specific mortality in AML patients receiving chemotherapy is higher than that in the general population.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.36948</identifier><identifier>PMID: 31762826</identifier><language>eng</language><publisher>Wyoming: Ivyspring International Publisher Pty Ltd</publisher><subject>Age groups ; Cancer therapies ; Cardiovascular disease ; Chemotherapy ; Cohort analysis ; Epidemiology ; Heart ; Leukemia ; Mortality ; Population ; Population-based studies ; Research Paper ; Socioeconomic factors ; Software</subject><ispartof>Journal of Cancer, 2019-01, Vol.10 (24), p.6161-6169</ispartof><rights>2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-bed9e398ea8f655ce0a9bf8d389601bdb0014da891cca2991e9ba056c47c0c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856578/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856578/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Li, Guangli</creatorcontrib><creatorcontrib>Zhou, Zhijuan</creatorcontrib><creatorcontrib>Yang, Wencong</creatorcontrib><creatorcontrib>Yang, Hao</creatorcontrib><creatorcontrib>Fan, Xiuwu</creatorcontrib><creatorcontrib>Yin, Yuelan</creatorcontrib><creatorcontrib>Luo, Liyun</creatorcontrib><creatorcontrib>Zhang, Jinyou</creatorcontrib><creatorcontrib>Wu, Niujian</creatorcontrib><creatorcontrib>Liang, Zibin</creatorcontrib><creatorcontrib>Ke, Jianting</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><title>Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis</title><title>Journal of Cancer</title><description>Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent with cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, patients diagnosed with AML between 1973 and 2015 were identified in the Surveillance, Epidemiology, and End Results database. Cumulative mortality by cause of death was calculated. To quantify the excessive cardiac-specific death compared with the general population, standardized mortality ratios (SMRs) were calculated. Multivariate Cox regression analyses were performed to identify risk factors associated with cardiac-specific death and AML-specific death. Results: A total of 64,679 AML patients were identified between 1973 and 2015; 68.48% of patients (44,292) received chemotherapy. Among all possible competing causes of death, AML was associated with the highest cumulative mortality. The AML patients who received chemotherapy showed excessive cardiac-specific mortality compared with the general population, with an SMR of 6.35 (95% CI: 5.89-6.82). Age, year of diagnosis, sex, and marital status were independently associated with patient prognosis. Conclusion: Cardiac-specific mortality in AML patients receiving chemotherapy is higher than that in the general population.</description><subject>Age groups</subject><subject>Cancer therapies</subject><subject>Cardiovascular disease</subject><subject>Chemotherapy</subject><subject>Cohort analysis</subject><subject>Epidemiology</subject><subject>Heart</subject><subject>Leukemia</subject><subject>Mortality</subject><subject>Population</subject><subject>Population-based studies</subject><subject>Research Paper</subject><subject>Socioeconomic factors</subject><subject>Software</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpd0c-O1SAUBnBiNM5knIVvQOJGEztCaSm4MDET_yU3cTN7ckpP53KFUoFq-gY-tuhMjMoGEn75cuAj5ClnVwPv2auThSshdacekHOuxNBoKbuHf53PyGXOJ1aX0O3QicfkTPBBtqqV5-THIS63TcEUqIU0ObBNXtG62VkaYirgXdkphKpo171sdUvBbgVp2NFHN1GP2xcMDugKxeFSMi0JoeBEv7typPaIIZYjJlj317SquG6-yrg0I-SqYAG_Z5efkEcz-IyX9_sFuXn_7ub6Y3P4_OHT9dtDY4VipRlx0ii0QlCz7HuLDPQ4q0koLRkfp5Ex3k2gNLcWWq056hFYL203WGa5uCBv7mLXbQw42TpxAm_W5AKk3URw5t-bxR3NbfxmpOplP6ga8Pw-IMWvG-ZigssWvYcF45ZNW_9WS671UOmz_-gpbqm-t6pe13oUE6yqF3fKpphzwvnPMJyZXw2b2rD53bD4CSVNmn4</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Li, Guangli</creator><creator>Zhou, Zhijuan</creator><creator>Yang, Wencong</creator><creator>Yang, Hao</creator><creator>Fan, Xiuwu</creator><creator>Yin, Yuelan</creator><creator>Luo, Liyun</creator><creator>Zhang, Jinyou</creator><creator>Wu, Niujian</creator><creator>Liang, Zibin</creator><creator>Ke, Jianting</creator><creator>Chen, Jian</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis</title><author>Li, Guangli ; Zhou, Zhijuan ; Yang, Wencong ; Yang, Hao ; Fan, Xiuwu ; Yin, Yuelan ; Luo, Liyun ; Zhang, Jinyou ; Wu, Niujian ; Liang, Zibin ; Ke, Jianting ; Chen, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-bed9e398ea8f655ce0a9bf8d389601bdb0014da891cca2991e9ba056c47c0c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age groups</topic><topic>Cancer therapies</topic><topic>Cardiovascular disease</topic><topic>Chemotherapy</topic><topic>Cohort analysis</topic><topic>Epidemiology</topic><topic>Heart</topic><topic>Leukemia</topic><topic>Mortality</topic><topic>Population</topic><topic>Population-based studies</topic><topic>Research Paper</topic><topic>Socioeconomic factors</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Guangli</creatorcontrib><creatorcontrib>Zhou, Zhijuan</creatorcontrib><creatorcontrib>Yang, Wencong</creatorcontrib><creatorcontrib>Yang, Hao</creatorcontrib><creatorcontrib>Fan, Xiuwu</creatorcontrib><creatorcontrib>Yin, Yuelan</creatorcontrib><creatorcontrib>Luo, Liyun</creatorcontrib><creatorcontrib>Zhang, Jinyou</creatorcontrib><creatorcontrib>Wu, Niujian</creatorcontrib><creatorcontrib>Liang, Zibin</creatorcontrib><creatorcontrib>Ke, Jianting</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guangli</au><au>Zhou, Zhijuan</au><au>Yang, Wencong</au><au>Yang, Hao</au><au>Fan, Xiuwu</au><au>Yin, Yuelan</au><au>Luo, Liyun</au><au>Zhang, Jinyou</au><au>Wu, Niujian</au><au>Liang, Zibin</au><au>Ke, Jianting</au><au>Chen, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis</atitle><jtitle>Journal of Cancer</jtitle><date>2019-01-01</date><risdate>2019</risdate><volume>10</volume><issue>24</issue><spage>6161</spage><epage>6169</epage><pages>6161-6169</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent with cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, patients diagnosed with AML between 1973 and 2015 were identified in the Surveillance, Epidemiology, and End Results database. Cumulative mortality by cause of death was calculated. To quantify the excessive cardiac-specific death compared with the general population, standardized mortality ratios (SMRs) were calculated. Multivariate Cox regression analyses were performed to identify risk factors associated with cardiac-specific death and AML-specific death. Results: A total of 64,679 AML patients were identified between 1973 and 2015; 68.48% of patients (44,292) received chemotherapy. Among all possible competing causes of death, AML was associated with the highest cumulative mortality. The AML patients who received chemotherapy showed excessive cardiac-specific mortality compared with the general population, with an SMR of 6.35 (95% CI: 5.89-6.82). Age, year of diagnosis, sex, and marital status were independently associated with patient prognosis. Conclusion: Cardiac-specific mortality in AML patients receiving chemotherapy is higher than that in the general population.</abstract><cop>Wyoming</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>31762826</pmid><doi>10.7150/jca.36948</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Cancer therapies Cardiovascular disease Chemotherapy Cohort analysis Epidemiology Heart Leukemia Mortality Population Population-based studies Research Paper Socioeconomic factors Software |
| title | Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis |
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