Fundamental roles of chromatin loop extrusion in antibody class switching

Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus ( Igh ) Cμ constant region exons (C H s) with one of six C H s lying 100–200 kb downstream 1 . Each C H is flanked upstream by an I promoter and long repetitive switch (S) region 1 . Cytokines and ac...

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Veröffentlicht in:	Nature (London) 2019-11, Vol.575 (7782), p.385-389
Hauptverfasser:	Zhang, Xuefei, Zhang, Yu, Ba, Zhaoqing, Kyritsis, Nia, Casellas, Rafael, Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/31 13/44 38 38/23 38/90 38/91 42/41 45 631/208 631/250/2152/2498 Analysis Animals Antibodies B-cell lymphoma Cells, Cultured Chromatin Chromatin - genetics Chromosome Pairing Class switching Cohesin Constant region Cytidine deaminase Cytidine Deaminase - deficiency Cytidine Deaminase - metabolism Cytokines Deamination Deoxyribonucleic acid DNA DNA repair Enhancers Exons Extrusion Genetic aspects Genetic recombination Genomes Heavy chains Humanities and Social Sciences Identification and classification Immunoglobulin Class Switching Immunoglobulin Heavy Chains Immunoglobulins Influence Insertion Lesions Lymphocytes Lymphocytes B Lymphoma Mice, Knockout multidisciplinary Mutation Recombination Science Science (multidisciplinary) Sequence Deletion Structure Switch genes Transcription Transcription, Genetic Viral antibodies
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