The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination

TANK-binding kinase 1 (TBK1) is essential for interferon beta (IFN-β) production and innate antiviral immunity. However, other, additional functions of TBK1 have remained elusive. Here, we showed that TBK1 is an E3 ubiquitin ligase that undergoes self-ubiquitylation in the presence of the E2 enzyme...

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Veröffentlicht in:	Journal of virology 2019-12, Vol.93 (23)
Hauptverfasser:	Li, Dan, Yang, Wenping, Ren, Jingjing, Ru, Yi, Zhang, Keshan, Fu, Shaozu, Liu, Xiangtao, Zheng, Haixue
Format:	Artikel
Sprache:	eng
Schlagworte:	Virus-Cell Interactions
Online-Zugang:	Volltext
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