Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa
Rhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was...
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| Veröffentlicht in: | Head & neck pathology (Totowa, N.J.) N.J.), 2019-12, Vol.13 (4), p.671-676 |
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| creator | Silva Cunha, John Lennon De Assis Almeida Lima-Júnior, Francisco Gonçalves Júnior, Wilson Déda De Santana Santos, Thiago Da Silveira, Ericka Janine Dantas De Sousa, Silvia Ferreira De Albuquerque-Júnior, Ricardo Luiz Cavalcanti |
| description | Rhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. A discussion on the clinical, histopathological, immunohistochemical and therapeutic aspects of botryoid RMS will be provided. |
| doi_str_mv | 10.1007/s12105-018-0957-8 |
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We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. 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We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. A discussion on the clinical, histopathological, immunohistochemical and therapeutic aspects of botryoid RMS will be provided.</description><subject>Adolescent</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Otorhinolaryngology</subject><subject>Pathology</subject><subject>Rhabdomyosarcoma, Embryonal - pathology</subject><subject>Sine qua non Clinicopathologic Correlation</subject><issn>1936-0568</issn><issn>1936-055X</issn><issn>1936-0568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LwzAYx4Mobk4_gBfpUQ_VJG1eehG2MV9AEXw5hyRNtkrbzKQV9u3N2Bzz4iVP4P-S8PwAOEfwGkHIbgLCCJIUIp7CgrCUH4AhKjKaQkL54d59AE5C-ISQQpbDYzDIICxyxugQPM4a5VeulXXyupCqdM3KBem1a2RyOXFd1KoyeetVt1qaq2RsrdFd1c6TbmGSSa91DD73OmZOwZGVdTBn2zkCH3ez9-lD-vRy_zgdP6U6z3GXllQzSoyWGimWc4psPI1SxEpMJMoYywhSvMRE2yLTJcElVkiS3CrEJbLZCNxuepe9akypTdt5WYulrxrpV8LJSvxV2moh5u5bUE5yRGksuNwWePfVm9CJpgra1LVsjeuDwJAzUmBGWbSijVV7F4I3dvcMgmKNQGwQiIhArBEIHjMX-__bJX53Hg14YwhRaufGi0_X-0gg_NP6A_L7kvY</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Silva Cunha, John Lennon</creator><creator>De Assis Almeida Lima-Júnior, Francisco</creator><creator>Gonçalves Júnior, Wilson Déda</creator><creator>De Santana Santos, Thiago</creator><creator>Da Silveira, Ericka Janine Dantas</creator><creator>De Sousa, Silvia Ferreira</creator><creator>De Albuquerque-Júnior, Ricardo Luiz Cavalcanti</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0679-8485</orcidid></search><sort><creationdate>20191201</creationdate><title>Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa</title><author>Silva Cunha, John Lennon ; De Assis Almeida Lima-Júnior, Francisco ; Gonçalves Júnior, Wilson Déda ; De Santana Santos, Thiago ; Da Silveira, Ericka Janine Dantas ; De Sousa, Silvia Ferreira ; De Albuquerque-Júnior, Ricardo Luiz Cavalcanti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-d6c765ecac1b74861f748ebb5fa25a1377351b8d25cf93cd52d2b1a54fb18a1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Otorhinolaryngology</topic><topic>Pathology</topic><topic>Rhabdomyosarcoma, Embryonal - pathology</topic><topic>Sine qua non Clinicopathologic Correlation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva Cunha, John Lennon</creatorcontrib><creatorcontrib>De Assis Almeida Lima-Júnior, Francisco</creatorcontrib><creatorcontrib>Gonçalves Júnior, Wilson Déda</creatorcontrib><creatorcontrib>De Santana Santos, Thiago</creatorcontrib><creatorcontrib>Da Silveira, Ericka Janine Dantas</creatorcontrib><creatorcontrib>De Sousa, Silvia Ferreira</creatorcontrib><creatorcontrib>De Albuquerque-Júnior, Ricardo Luiz Cavalcanti</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva Cunha, John Lennon</au><au>De Assis Almeida Lima-Júnior, Francisco</au><au>Gonçalves Júnior, Wilson Déda</au><au>De Santana Santos, Thiago</au><au>Da Silveira, Ericka Janine Dantas</au><au>De Sousa, Silvia Ferreira</au><au>De Albuquerque-Júnior, Ricardo Luiz Cavalcanti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa</atitle><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle><stitle>Head and Neck Pathol</stitle><addtitle>Head Neck Pathol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>13</volume><issue>4</issue><spage>671</spage><epage>676</epage><pages>671-676</pages><issn>1936-0568</issn><issn>1936-055X</issn><eissn>1936-0568</eissn><abstract>Rhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. 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| subjects | Adolescent Dentistry Female Humans Medicine Medicine & Public Health Mouth Mucosa - pathology Mouth Neoplasms - pathology Oral and Maxillofacial Surgery Otorhinolaryngology Pathology Rhabdomyosarcoma, Embryonal - pathology Sine qua non Clinicopathologic Correlation |
| title | Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa |
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