Direct Conversion of Human Urine Cells to Neurons by Small Molecules

Transdifferentiation of other cell type into human neuronal cells (hNCs) provides a platform for neural disease modeling, drug screening and potential cell-based therapies. Among all of the cell donor sources, human urine cells (hUCs) are convenient to obtain without invasive harvest procedure. Here...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16707-10, Article 16707
Hauptverfasser:	Xu, Guosheng, Wu, Feima, Gu, Xiaotong, Zhang, Jiaye, You, Kai, Chen, Yan, Getachew, Anteneh, Zhuang, Yuanqi, Zhong, Xiaofen, Lin, Zuoxian, Guo, Dongsheng, Yang, Fan, Pan, Tingcai, Wei, Hongcheng, Li, Yin-xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/19 38/77 631/378/87 631/532/2128 Adult Cell Differentiation Cellular Reprogramming Cytology Dopamine receptors Drug screening Glutamatergic transmission Humanities and Social Sciences Humans Male Morphology Motor neurons multidisciplinary Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Science Science (multidisciplinary) Small Molecule Libraries - pharmacology Urine Urine - cytology γ-Aminobutyric acid
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