Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells

In addition to antigen-driven signals, T cells need co-stimulatory signals for robust activation. Several receptors, including members of the tumor necrosis factor receptor superfamily (TNFRSF), can deliver co-stimulatory signals to T cells. Thioredoxin interacting protein (TXNIP) is an important in...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16725-13, Article 16725
Hauptverfasser:	Levring, Trine B., Kongsbak-Wismann, Martin, Rode, Anna K. O., Al-Jaberi, Fatima A. H., Lopez, Daniel V., Met, Özcan, Woetmann, Anders, Bonefeld, Charlotte M., Ødum, Niels, Geisler, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/95 631/250/1619/554 631/250/516 82 82/80 Blood Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism Caspase Cell activation Cell proliferation Centrifugation Down-Regulation Glucose - metabolism Humanities and Social Sciences Humans Ligands Lymphocytes Lymphocytes T multidisciplinary Necrosis Science Science (multidisciplinary) T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thioredoxin Toll-like receptors Toll-Like Receptors - agonists Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF
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