An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes

RATIONALE:Human pluripotent stem cell (hPSC)–derived cardiomyocytes exhibit the properties of fetal cardiomyocytes, which limits their applications. Various methods have been used to promote maturation of hPSC-cardiomyocytes; however, there is a lack of an unbiased and comprehensive method for accur...

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Veröffentlicht in:	Circulation research 2019-11, Vol.125 (11), p.936-953
Hauptverfasser:	Cai, Wenxuan, Zhang, Jianhua, de Lange, Willem J, Gregorich, Zachery R, Karp, Hannah, Farrell, Emily T, Mitchell, Stanford D, Tucholski, Trisha, Lin, Ziqing, Biermann, Mitch, McIlwain, Sean J, Ralphe, J Carter, Kamp, Timothy J, Ge, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Cell Culture Techniques Cell Differentiation Cell Line Chromatography, Liquid High-Throughput Screening Assays Humans Induced Pluripotent Stem Cells - metabolism Myocytes, Cardiac - metabolism Phenotype Proteins - metabolism Proteomics - methods Reproducibility of Results Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Time Factors
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