Clonal evolution of acute myeloid leukemia from diagnosis to relapse

Based on the individual genetic profile, acute myeloid leukemia (AML) patients are classified into clinically meaningful molecular subtypes. However, the mutational profile within these groups is highly heterogeneous and multiple AML subclones may exist in a single patient in parallel. Distinct alte...

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Veröffentlicht in:	Genes chromosomes & cancer 2019-12, Vol.58 (12), p.839-849
Hauptverfasser:	Vosberg, Sebastian, Greif, Philipp A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Biological evolution Cell survival Chemotherapy Chronic Disease clonal evolution Clonal Evolution - genetics Evolution Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - physiopathology Myeloid leukemia Natural selection next generation sequencing Recurrence Regrowth relapse Remission Remission Induction Review therapy resistance
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