Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study
To assess the effects of single nucleotide polymorphisms (SNPs) on blood pressure control in patients with obstructive sleep apnea (OSA). This prospective observational cohort study, conducted between 2004 and 2014, examined the associations of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and NPR3-C5orf23...
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| Veröffentlicht in: | Croatian medical journal 2019-10, Vol.60 (5), p.421-430 |
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| container_title | Croatian medical journal |
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| creator | Paraničová, Ivana Habalová, Viera Klimčáková, Lucia Trojová, Ivana Židzik, Jozef Tkáč, Ivan Tkáčová, Ružena Joppa, Pavol |
| description | To assess the effects of single nucleotide polymorphisms (SNPs) on blood pressure control in patients with obstructive sleep apnea (OSA).
This prospective observational cohort study, conducted between 2004 and 2014, examined the associations of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and NPR3-C5orf23 genes with systolic and diastolic blood pressure (SBP, DBP) in 1179 adults evaluated for OSA with overnight polysomnography. Genotyping was performed by unlabeled probe melting analysis.
The patients were predominantly male (69.6%, mean age 52±11 years, apnea-hypopnea index 34±31 episodes/h). Only JAG1 genotype was associated with SBP and DBP: compared with AA homozygotes, G allele carriers (pooled GG and AG genotype) had significantly higher morning SBP (132±19 vs 129±18 mm Hg; P=0.009) and morning and evening DBP (85±11 vs 83±10 mm Hg, P=0.004; 86±10 vs 84±10 mm Hg, P=0.012, respectively); the differences remained significant after the correction for multiple SNPs testing. In multivariate analyses, oxygen desaturation index and JAG1 genotype independently predicted morning SBP (P=0.001, P=0.003, respectively) and DBP (P |
| doi_str_mv | 10.3325/cmj.2019.60.421 |
| format | Article |
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This prospective observational cohort study, conducted between 2004 and 2014, examined the associations of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and NPR3-C5orf23 genes with systolic and diastolic blood pressure (SBP, DBP) in 1179 adults evaluated for OSA with overnight polysomnography. Genotyping was performed by unlabeled probe melting analysis.
The patients were predominantly male (69.6%, mean age 52±11 years, apnea-hypopnea index 34±31 episodes/h). Only JAG1 genotype was associated with SBP and DBP: compared with AA homozygotes, G allele carriers (pooled GG and AG genotype) had significantly higher morning SBP (132±19 vs 129±18 mm Hg; P=0.009) and morning and evening DBP (85±11 vs 83±10 mm Hg, P=0.004; 86±10 vs 84±10 mm Hg, P=0.012, respectively); the differences remained significant after the correction for multiple SNPs testing. In multivariate analyses, oxygen desaturation index and JAG1 genotype independently predicted morning SBP (P=0.001, P=0.003, respectively) and DBP (P<0.001, P=0.005, respectively), and evening SBP (P=0.019, P=0.048, respectively) and DBP (P=0.018, P=0.018, respectively).
This is the first replication study of the SNPs recently linked to arterial hypertension in general population by genome-wide association studies. Our findings suggest that JAG1 genotype is related to blood pressure control in OSA: G allele was associated with higher morning and evening SBP and DBP.</description><identifier>ISSN: 0353-9504</identifier><identifier>EISSN: 1332-8166</identifier><identifier>DOI: 10.3325/cmj.2019.60.421</identifier><identifier>PMID: 31686456</identifier><identifier>CODEN: CMEJEN</identifier><language>eng</language><publisher>Croatia: Sveuciliste U Zagrebu</publisher><subject>Adult ; Analysis ; Apnea ; Blood pressure ; Blood Pressure - physiology ; Care and treatment ; Chromosomes ; Female ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genome-Wide Association Study ; Genomics ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - epidemiology ; Jagged-1 Protein - genetics ; Male ; Middle Aged ; Prospective Studies ; Respiration disorders ; Single nucleotide polymorphisms ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - genetics ; Type 2 diabetes</subject><ispartof>Croatian medical journal, 2019-10, Vol.60 (5), p.421-430</ispartof><rights>COPYRIGHT 2019 Sveuciliste U Zagrebu</rights><rights>Copyright © 2019 by the Croatian Medical Journal. All rights reserved. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5055-0682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852136/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852136/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31686456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paraničová, Ivana</creatorcontrib><creatorcontrib>Habalová, Viera</creatorcontrib><creatorcontrib>Klimčáková, Lucia</creatorcontrib><creatorcontrib>Trojová, Ivana</creatorcontrib><creatorcontrib>Židzik, Jozef</creatorcontrib><creatorcontrib>Tkáč, Ivan</creatorcontrib><creatorcontrib>Tkáčová, Ružena</creatorcontrib><creatorcontrib>Joppa, Pavol</creatorcontrib><title>Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study</title><title>Croatian medical journal</title><addtitle>Croat Med J</addtitle><description>To assess the effects of single nucleotide polymorphisms (SNPs) on blood pressure control in patients with obstructive sleep apnea (OSA).
This prospective observational cohort study, conducted between 2004 and 2014, examined the associations of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and NPR3-C5orf23 genes with systolic and diastolic blood pressure (SBP, DBP) in 1179 adults evaluated for OSA with overnight polysomnography. Genotyping was performed by unlabeled probe melting analysis.
The patients were predominantly male (69.6%, mean age 52±11 years, apnea-hypopnea index 34±31 episodes/h). Only JAG1 genotype was associated with SBP and DBP: compared with AA homozygotes, G allele carriers (pooled GG and AG genotype) had significantly higher morning SBP (132±19 vs 129±18 mm Hg; P=0.009) and morning and evening DBP (85±11 vs 83±10 mm Hg, P=0.004; 86±10 vs 84±10 mm Hg, P=0.012, respectively); the differences remained significant after the correction for multiple SNPs testing. In multivariate analyses, oxygen desaturation index and JAG1 genotype independently predicted morning SBP (P=0.001, P=0.003, respectively) and DBP (P<0.001, P=0.005, respectively), and evening SBP (P=0.019, P=0.048, respectively) and DBP (P=0.018, P=0.018, respectively).
This is the first replication study of the SNPs recently linked to arterial hypertension in general population by genome-wide association studies. Our findings suggest that JAG1 genotype is related to blood pressure control in OSA: G allele was associated with higher morning and evening SBP and DBP.</description><subject>Adult</subject><subject>Analysis</subject><subject>Apnea</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Care and treatment</subject><subject>Chromosomes</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genome-Wide Association Study</subject><subject>Genomics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Jagged-1 Protein - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Respiration disorders</subject><subject>Single nucleotide polymorphisms</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - genetics</subject><subject>Type 2 diabetes</subject><issn>0353-9504</issn><issn>1332-8166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkk1v1DAQhiMEokvhzA1ZQkJcsvX3xhwqrSoooEpc4Gw5zmTjksTBdor2F_C3cZRSdSXkg63x845nPG9RvCZ4yxgVF3a43VJM1FbiLafkSbEhOV5WRMqnxQYzwUolMD8rXsR4izHFnMvnxRkjspJcyE3xZx-jt84k50fkW_R1f03QAUZAk--Pgw9T5-KAfrvUoXiMCQZnUd1736ApQIxzAORGNOUEMKa4gr6OKcw2uTtAsQeYkJlGMB-QySIfJ1ivrO98SCimuTm-LJ61po_w6n4_L358-vj96nN58-36y9X-prS8YqlsK6yqnVVqZxStuKqMkCAq1sgGcGtqS6kg2OxETRinEiuuqJCMCcutrFXLzovLNe801wM0NhcdTK-n4AYTjtobp09vRtfpg7_TshKUMJkTlGuCLljz80S4RmKwkI-ackzwwr-_fzD4XzPEpAcXLfS9GcHPUVNGKN3lplhG367owfSg3dj6XIFdcL2XhIpdpaTK1PY_VF7NMhs_Quty_ETw7pGgA9OnLvp-XkYeT8GLFbR5SDFA-9AdwXqxm85204vdtMQ62y0r3jz-zQf-n7_YX_sE0jA</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Paraničová, Ivana</creator><creator>Habalová, Viera</creator><creator>Klimčáková, Lucia</creator><creator>Trojová, Ivana</creator><creator>Židzik, Jozef</creator><creator>Tkáč, Ivan</creator><creator>Tkáčová, Ružena</creator><creator>Joppa, Pavol</creator><general>Sveuciliste U Zagrebu</general><general>Medicinski fakultet Sveučilišta u Zagrebu, Medicinski fakultet Sveučilišta u Splitu, Medicinski fakultet Sveučilišta u Rijeci</general><general>Croatian Medical Schools</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>VP8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5055-0682</orcidid></search><sort><creationdate>20191001</creationdate><title>Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study</title><author>Paraničová, Ivana ; Habalová, Viera ; Klimčáková, Lucia ; Trojová, Ivana ; Židzik, Jozef ; Tkáč, Ivan ; Tkáčová, Ružena ; Joppa, Pavol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-f80987c997a928498a56e583d6de0fabc22510a75b134260949256335c4c6b9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Apnea</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Care and treatment</topic><topic>Chromosomes</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genome-Wide Association Study</topic><topic>Genomics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Jagged-1 Protein - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Respiration disorders</topic><topic>Single nucleotide polymorphisms</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep Apnea, Obstructive - genetics</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paraničová, Ivana</creatorcontrib><creatorcontrib>Habalová, Viera</creatorcontrib><creatorcontrib>Klimčáková, Lucia</creatorcontrib><creatorcontrib>Trojová, Ivana</creatorcontrib><creatorcontrib>Židzik, Jozef</creatorcontrib><creatorcontrib>Tkáč, Ivan</creatorcontrib><creatorcontrib>Tkáčová, Ružena</creatorcontrib><creatorcontrib>Joppa, Pavol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Croatian medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paraničová, Ivana</au><au>Habalová, Viera</au><au>Klimčáková, Lucia</au><au>Trojová, Ivana</au><au>Židzik, Jozef</au><au>Tkáč, Ivan</au><au>Tkáčová, Ružena</au><au>Joppa, Pavol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study</atitle><jtitle>Croatian medical journal</jtitle><addtitle>Croat Med J</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>60</volume><issue>5</issue><spage>421</spage><epage>430</epage><pages>421-430</pages><issn>0353-9504</issn><eissn>1332-8166</eissn><coden>CMEJEN</coden><abstract>To assess the effects of single nucleotide polymorphisms (SNPs) on blood pressure control in patients with obstructive sleep apnea (OSA).
This prospective observational cohort study, conducted between 2004 and 2014, examined the associations of SNPs of JAG1, GUCY1A3-GUCY1B3, SH2B3, and NPR3-C5orf23 genes with systolic and diastolic blood pressure (SBP, DBP) in 1179 adults evaluated for OSA with overnight polysomnography. Genotyping was performed by unlabeled probe melting analysis.
The patients were predominantly male (69.6%, mean age 52±11 years, apnea-hypopnea index 34±31 episodes/h). Only JAG1 genotype was associated with SBP and DBP: compared with AA homozygotes, G allele carriers (pooled GG and AG genotype) had significantly higher morning SBP (132±19 vs 129±18 mm Hg; P=0.009) and morning and evening DBP (85±11 vs 83±10 mm Hg, P=0.004; 86±10 vs 84±10 mm Hg, P=0.012, respectively); the differences remained significant after the correction for multiple SNPs testing. In multivariate analyses, oxygen desaturation index and JAG1 genotype independently predicted morning SBP (P=0.001, P=0.003, respectively) and DBP (P<0.001, P=0.005, respectively), and evening SBP (P=0.019, P=0.048, respectively) and DBP (P=0.018, P=0.018, respectively).
This is the first replication study of the SNPs recently linked to arterial hypertension in general population by genome-wide association studies. Our findings suggest that JAG1 genotype is related to blood pressure control in OSA: G allele was associated with higher morning and evening SBP and DBP.</abstract><cop>Croatia</cop><pub>Sveuciliste U Zagrebu</pub><pmid>31686456</pmid><doi>10.3325/cmj.2019.60.421</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5055-0682</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Croatian medical journal, 2019-10, Vol.60 (5), p.421-430 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Analysis Apnea Blood pressure Blood Pressure - physiology Care and treatment Chromosomes Female Genes Genetic aspects Genetic polymorphisms Genome-Wide Association Study Genomics Humans Hypertension Hypertension - complications Hypertension - epidemiology Jagged-1 Protein - genetics Male Middle Aged Prospective Studies Respiration disorders Single nucleotide polymorphisms Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - genetics Type 2 diabetes |
| title | Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study |
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