Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet
Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d -fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the developme...
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| Veröffentlicht in: | Scientific reports 2019-11, Vol.9 (1), p.16628-12, Article 16628 |
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| creator | Hereu, Mercè Ramos-Romero, Sara Busquets, Cristina Atienza, Lidia Amézqueta, Susana Miralles-Pérez, Bernat Nogués, Maria Rosa Méndez, Lucía Medina, Isabel Torres, Josep Lluís |
| description | Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of
d
-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with
d
-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with
d
-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of
d
-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of
d
-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs. |
| doi_str_mv | 10.1038/s41598-019-52678-5 |
| format | Article |
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d
-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with
d
-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with
d
-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of
d
-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of
d
-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-52678-5</identifier><identifier>PMID: 31719544</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/63 ; 45/22 ; 45/77 ; 631/443/319/1642/2815 ; 692/700/2814 ; Animals ; Bioactive compounds ; Blood Glucose - analysis ; Cecum ; Developmental stages ; Diabetes ; Diabetes mellitus ; Diet ; Diet, High-Fat - adverse effects ; Dietary supplements ; Drug Therapy, Combination ; Dysbacteriosis ; Fatty acids ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - therapeutic use ; Fish oils ; Gastrointestinal Microbiome - drug effects ; Glucose tolerance ; Glucose Tolerance Test ; Health risks ; High fat diet ; Humanities and Social Sciences ; Imino Pyranoses - administration & dosage ; Imino Pyranoses - therapeutic use ; Inflammation ; Insulin ; Insulin - blood ; Intestinal microflora ; Leptin - blood ; Liver ; Male ; Microbiota ; multidisciplinary ; Polyunsaturated fatty acids ; Prediabetic State - etiology ; Prediabetic State - microbiology ; Prediabetic State - prevention & control ; Rats ; Rats, Sprague-Dawley ; Risk Factors ; Science ; Science (multidisciplinary) ; Subpopulations</subject><ispartof>Scientific reports, 2019-11, Vol.9 (1), p.16628-12, Article 16628</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-c54b4df0c7b9bdb2a64ec277f1fc7aba2354e8b8b417cb7e599472d333acbf6f3</citedby><cites>FETCH-LOGICAL-c474t-c54b4df0c7b9bdb2a64ec277f1fc7aba2354e8b8b417cb7e599472d333acbf6f3</cites><orcidid>0000-0002-7349-8802</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851385/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851385/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31719544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hereu, Mercè</creatorcontrib><creatorcontrib>Ramos-Romero, Sara</creatorcontrib><creatorcontrib>Busquets, Cristina</creatorcontrib><creatorcontrib>Atienza, Lidia</creatorcontrib><creatorcontrib>Amézqueta, Susana</creatorcontrib><creatorcontrib>Miralles-Pérez, Bernat</creatorcontrib><creatorcontrib>Nogués, Maria Rosa</creatorcontrib><creatorcontrib>Méndez, Lucía</creatorcontrib><creatorcontrib>Medina, Isabel</creatorcontrib><creatorcontrib>Torres, Josep Lluís</creatorcontrib><title>Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of
d
-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with
d
-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with
d
-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of
d
-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of
d
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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hereu, Mercè</au><au>Ramos-Romero, Sara</au><au>Busquets, Cristina</au><au>Atienza, Lidia</au><au>Amézqueta, Susana</au><au>Miralles-Pérez, Bernat</au><au>Nogués, Maria Rosa</au><au>Méndez, Lucía</au><au>Medina, Isabel</au><au>Torres, Josep Lluís</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-11-12</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>16628</spage><epage>12</epage><pages>16628-12</pages><artnum>16628</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of
d
-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with
d
-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with
d
-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of
d
-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of
d
-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31719544</pmid><doi>10.1038/s41598-019-52678-5</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7349-8802</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 2045-2322 2045-2322 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 14/63 45/22 45/77 631/443/319/1642/2815 692/700/2814 Animals Bioactive compounds Blood Glucose - analysis Cecum Developmental stages Diabetes Diabetes mellitus Diet Diet, High-Fat - adverse effects Dietary supplements Drug Therapy, Combination Dysbacteriosis Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - therapeutic use Fish oils Gastrointestinal Microbiome - drug effects Glucose tolerance Glucose Tolerance Test Health risks High fat diet Humanities and Social Sciences Imino Pyranoses - administration & dosage Imino Pyranoses - therapeutic use Inflammation Insulin Insulin - blood Intestinal microflora Leptin - blood Liver Male Microbiota multidisciplinary Polyunsaturated fatty acids Prediabetic State - etiology Prediabetic State - microbiology Prediabetic State - prevention & control Rats Rats, Sprague-Dawley Risk Factors Science Science (multidisciplinary) Subpopulations |
| title | Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet |
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