Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3
Fermented foods represent a significant portion of human diets with several beneficial effects. Foods produced by bacterial fermentation are enriched in short-chain fatty acids (SCFAs), which are functional products of dietary fibers via gut microbial fermentation. In addition to energy sources, SCF...
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| Veröffentlicht in: | Scientific reports 2019-11, Vol.9 (1), p.16574-10, Article 16574 |
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| description | Fermented foods represent a significant portion of human diets with several beneficial effects. Foods produced by bacterial fermentation are enriched in short-chain fatty acids (SCFAs), which are functional products of dietary fibers via gut microbial fermentation. In addition to energy sources, SCFAs also act as signaling molecules via G-protein coupled receptors such as FFAR2 and FFAR3. Hence, dietary SCFAs in fermented foods may have a direct influence on metabolic functions. However, the detailed mechanism by dietary SCFAs remains unclear. Here, we show that dietary SCFAs protected against high-fat diet-induced obesity in mice in parallel with increased plasma SCFAs without changing cecal SCFA or gut microbial composition. Dietary SCFAs suppressed hepatic weight and lipid synthesis. These effects were abolished in FFAR3-deficient mice but not FFAR2-deficient. Thus, SCFAs supplementation improved hepatic metabolic functions via FFAR3 without influencing intestinal environment. These findings could help to promote the development of functional foods using SCFAs. |
| doi_str_mv | 10.1038/s41598-019-53242-x |
| format | Article |
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Foods produced by bacterial fermentation are enriched in short-chain fatty acids (SCFAs), which are functional products of dietary fibers via gut microbial fermentation. In addition to energy sources, SCFAs also act as signaling molecules via G-protein coupled receptors such as FFAR2 and FFAR3. Hence, dietary SCFAs in fermented foods may have a direct influence on metabolic functions. However, the detailed mechanism by dietary SCFAs remains unclear. Here, we show that dietary SCFAs protected against high-fat diet-induced obesity in mice in parallel with increased plasma SCFAs without changing cecal SCFA or gut microbial composition. Dietary SCFAs suppressed hepatic weight and lipid synthesis. These effects were abolished in FFAR3-deficient mice but not FFAR2-deficient. Thus, SCFAs supplementation improved hepatic metabolic functions via FFAR3 without influencing intestinal environment. 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Foods produced by bacterial fermentation are enriched in short-chain fatty acids (SCFAs), which are functional products of dietary fibers via gut microbial fermentation. In addition to energy sources, SCFAs also act as signaling molecules via G-protein coupled receptors such as FFAR2 and FFAR3. Hence, dietary SCFAs in fermented foods may have a direct influence on metabolic functions. However, the detailed mechanism by dietary SCFAs remains unclear. Here, we show that dietary SCFAs protected against high-fat diet-induced obesity in mice in parallel with increased plasma SCFAs without changing cecal SCFA or gut microbial composition. Dietary SCFAs suppressed hepatic weight and lipid synthesis. These effects were abolished in FFAR3-deficient mice but not FFAR2-deficient. Thus, SCFAs supplementation improved hepatic metabolic functions via FFAR3 without influencing intestinal environment. These findings could help to promote the development of functional foods using SCFAs.</description><subject>38/77</subject><subject>45/22</subject><subject>45/23</subject><subject>45/41</subject><subject>631/337</subject><subject>631/443/319/2723</subject><subject>64/60</subject><subject>692/163/2743</subject><subject>692/700/459/1994</subject><subject>Animals</subject><subject>Cecum</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dietary intake</subject><subject>Dietary supplements</subject><subject>Digestive system</subject><subject>Energy sources</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - blood</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Feeding Behavior</subject><subject>Fermentation</subject><subject>Fermented food</subject><subject>Fibers</subject><subject>Food</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastrointestinal tract</subject><subject>Gene Expression Regulation</subject><subject>High fat diet</subject><subject>Humanities and Social Sciences</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Lipid Metabolism - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Hidenori</au><au>Masujima, Yuki</au><au>Ushiroda, Chihiro</au><au>Mizushima, Rina</au><au>Taira, Satsuki</au><au>Ohue-Kitano, Ryuji</au><au>Kimura, Ikuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-11-12</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>16574</spage><epage>10</epage><pages>16574-10</pages><artnum>16574</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Fermented foods represent a significant portion of human diets with several beneficial effects. Foods produced by bacterial fermentation are enriched in short-chain fatty acids (SCFAs), which are functional products of dietary fibers via gut microbial fermentation. In addition to energy sources, SCFAs also act as signaling molecules via G-protein coupled receptors such as FFAR2 and FFAR3. Hence, dietary SCFAs in fermented foods may have a direct influence on metabolic functions. However, the detailed mechanism by dietary SCFAs remains unclear. Here, we show that dietary SCFAs protected against high-fat diet-induced obesity in mice in parallel with increased plasma SCFAs without changing cecal SCFA or gut microbial composition. Dietary SCFAs suppressed hepatic weight and lipid synthesis. These effects were abolished in FFAR3-deficient mice but not FFAR2-deficient. Thus, SCFAs supplementation improved hepatic metabolic functions via FFAR3 without influencing intestinal environment. These findings could help to promote the development of functional foods using SCFAs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31719611</pmid><doi>10.1038/s41598-019-53242-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8778-145X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 38/77 45/22 45/23 45/41 631/337 631/443/319/2723 64/60 692/163/2743 692/700/459/1994 Animals Cecum Diet Dietary fiber Dietary intake Dietary supplements Digestive system Energy sources Fatty acids Fatty Acids, Volatile - blood Fatty Acids, Volatile - metabolism Feeding Behavior Fermentation Fermented food Fibers Food Functional foods & nutraceuticals Gastrointestinal tract Gene Expression Regulation High fat diet Humanities and Social Sciences Intestinal microflora Intestine Lipid Metabolism - genetics Liver Liver - metabolism Male Metabolism Mice, Inbred C57BL multidisciplinary Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) |
| title | Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3 |
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