Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line

The proximal tubule is a particularly important site for ageing-related kidney damage. Sirtuin 1 (SIRT1), an NAD + (nicotinamide adenine dinucleotide)-dependent deacetylase in the proximal tubule, may be involved in renal injury associated with ageing. However, the mechanisms of SIRT1 regulation rem...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16550-11, Article 16550
Hauptverfasser:	Yamaji, Takahiro, Yamashita, Akio, Wakui, Hiromichi, Azushima, Kengo, Uneda, Kazushi, Fujikawa, Yumiko, Haku, Sona, Kobayashi, Ryu, Ohki, Kohji, Haruhara, Kotaro, Kinguchi, Sho, Ishii, Takeo, Yamada, Takayuki, Urate, Shingo, Suzuki, Toru, Abe, Eriko, Tanaka, Shohei, Kamimura, Daisuke, Ishigami, Tomoaki, Toya, Yoshiyuki, Takahashi, Hidehisa, Tamura, Kouichi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 38 38/1 631/80 692/4022/1585/104 Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenine Aging Angiotensin Angiotensin II Angiotensin II - pharmacology Biomarkers - metabolism Cell Line Cell Line, Transformed Clone Cells Epithelial cells Epithelial Cells - metabolism Fibrosis Gene expression Gene Expression Regulation - drug effects Humanities and Social Sciences Humans Kidney diseases Kidney Tubules, Distal - metabolism Kidneys multidisciplinary NAD Nicotinamide Protein deficiency Protein expression Proteins Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Renal function RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Sodium
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