Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project
Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidan...
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| Veröffentlicht in: | Haemophilia : the official journal of the World Federation of Hemophilia 2019-07, Vol.25 (4), p.656-667 |
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| container_title | Haemophilia : the official journal of the World Federation of Hemophilia |
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| creator | Santagostino, Elena Riva, Agostino Cesaro, Simone Esposito, Susanna Matino, Davide Mazzucchelli, Renata Ilde Molinari, Angelo Claudio Mura, Rosamaria Notarangelo, Lucia Dora Tagliaferri, Annarita Di Minno, Giovanni Clerici, Mario Ambaglio, Chiara Brigida Aru, Anna Baldacci, Erminia Barillari, Giovanni Basso, Maria Bernasconi, Sayla Bertamino, Marta Bertoni, Elisa Biasoli, Chiara Federica Biguzzi, Eugenia Bonetti, Elisa Borchiellini, Alessandra Bulgarelli, Simona Cabibbo, Sergio Cantori, Isabella Castaman, Giancarlo Castiglia, Paolo Coluccia, Antonella Coppetelli, Ugo Coppola, Antonio Cultrera, Dorina De Candia, Erica Delios, Grazia Di Gennaro, Leonardo Di Gregorio, Patrizia Di Minno, Matteo Dragani, Alfredo Pietro Ettorre, Cosimo Franchini, Massimo Galli, Massimo Gallo, Giovanni Giordano, Paola Giuffrida, Gaetano Iannaccaro, Piergiorgio Lassandro, Giuseppe Lazzareschi, Ilaria Linari, Silvia Luciani, Matteo Macchi, Silvia Malcangi, Giuseppe Malizia, Raniero Marietta, Marco Marino, Renato Massoud, Michela Gabriella Mazzucconi, Maria Milan, Marta Morfini, Massimo Napolitano, Mariasanta Pasca, Samantha Pedrazzi, Paola Peyvandi, Flora A. Piscitelli, Lydia Pollio, Berardino Preti, Paola Quintavalle, Gabriele Radossi, Paolo Raso, Simona Ricca, Irene Rocino, Angiola Santoro, Cristina Carlotta Santoro, Rita Sarolo, Lucia Schiavoni, Mario Schiavulli, Michele Sciancalepore, Patrizia Luisa Serino, Maria Mario Siragusa, Sergio Sottilotta, Gianluca Svahn, Johanna Valdrè, Lelia Cristina Vedovati, Maria Zanon, Ezio |
| description | Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5‐point Likert‐type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence‐ and consensus‐based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement. |
| doi_str_mv | 10.1111/hae.13756 |
| format | Article |
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Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5‐point Likert‐type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence‐ and consensus‐based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.</description><identifier>ISSN: 1351-8216</identifier><identifier>ISSN: 1365-2516</identifier><identifier>EISSN: 1365-2516</identifier><identifier>DOI: 10.1111/hae.13756</identifier><identifier>PMID: 30990961</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Bleeding ; bleeding disorder ; Child ; Coagulation factor VIII ; Coagulation factors ; Consensus ; Delphi Technique ; Evidence-Based Medicine ; factor VIII inhibitor ; haemophilia ; Hemophilia ; Hemophilia A - prevention & control ; Hemophilia B - prevention & control ; Humans ; Immunization ; Italy ; Original ; Vaccination ; Vaccines</subject><ispartof>Haemophilia : the official journal of the World Federation of Hemophilia, 2019-07, Vol.25 (4), p.656-667</ispartof><rights>2019 The Authors. Haemophilia Published by John Wiley & Sons Ltd</rights><rights>2019 The Authors. 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View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santagostino, Elena</creatorcontrib><creatorcontrib>Riva, Agostino</creatorcontrib><creatorcontrib>Cesaro, Simone</creatorcontrib><creatorcontrib>Esposito, Susanna</creatorcontrib><creatorcontrib>Matino, Davide</creatorcontrib><creatorcontrib>Mazzucchelli, Renata Ilde</creatorcontrib><creatorcontrib>Molinari, Angelo Claudio</creatorcontrib><creatorcontrib>Mura, Rosamaria</creatorcontrib><creatorcontrib>Notarangelo, Lucia Dora</creatorcontrib><creatorcontrib>Tagliaferri, Annarita</creatorcontrib><creatorcontrib>Di Minno, Giovanni</creatorcontrib><creatorcontrib>Clerici, Mario</creatorcontrib><creatorcontrib>Ambaglio, Chiara</creatorcontrib><creatorcontrib>Brigida Aru, Anna</creatorcontrib><creatorcontrib>Baldacci, Erminia</creatorcontrib><creatorcontrib>Barillari, Giovanni</creatorcontrib><creatorcontrib>Basso, Maria</creatorcontrib><creatorcontrib>Bernasconi, Sayla</creatorcontrib><creatorcontrib>Bertamino, Marta</creatorcontrib><creatorcontrib>Bertoni, Elisa</creatorcontrib><creatorcontrib>Biasoli, Chiara</creatorcontrib><creatorcontrib>Federica Biguzzi, Eugenia</creatorcontrib><creatorcontrib>Bonetti, Elisa</creatorcontrib><creatorcontrib>Borchiellini, Alessandra</creatorcontrib><creatorcontrib>Bulgarelli, Simona</creatorcontrib><creatorcontrib>Cabibbo, Sergio</creatorcontrib><creatorcontrib>Cantori, Isabella</creatorcontrib><creatorcontrib>Castaman, Giancarlo</creatorcontrib><creatorcontrib>Castiglia, Paolo</creatorcontrib><creatorcontrib>Coluccia, Antonella</creatorcontrib><creatorcontrib>Coppetelli, Ugo</creatorcontrib><creatorcontrib>Coppola, Antonio</creatorcontrib><creatorcontrib>Cultrera, Dorina</creatorcontrib><creatorcontrib>De Candia, Erica</creatorcontrib><creatorcontrib>Delios, Grazia</creatorcontrib><creatorcontrib>Di Gennaro, Leonardo</creatorcontrib><creatorcontrib>Di Gregorio, Patrizia</creatorcontrib><creatorcontrib>Di Minno, Matteo</creatorcontrib><creatorcontrib>Dragani, Alfredo</creatorcontrib><creatorcontrib>Pietro Ettorre, Cosimo</creatorcontrib><creatorcontrib>Franchini, Massimo</creatorcontrib><creatorcontrib>Galli, Massimo</creatorcontrib><creatorcontrib>Gallo, Giovanni</creatorcontrib><creatorcontrib>Giordano, Paola</creatorcontrib><creatorcontrib>Giuffrida, Gaetano</creatorcontrib><creatorcontrib>Iannaccaro, Piergiorgio</creatorcontrib><creatorcontrib>Lassandro, Giuseppe</creatorcontrib><creatorcontrib>Lazzareschi, Ilaria</creatorcontrib><creatorcontrib>Linari, Silvia</creatorcontrib><creatorcontrib>Luciani, Matteo</creatorcontrib><creatorcontrib>Macchi, Silvia</creatorcontrib><creatorcontrib>Malcangi, Giuseppe</creatorcontrib><creatorcontrib>Malizia, Raniero</creatorcontrib><creatorcontrib>Marietta, Marco</creatorcontrib><creatorcontrib>Marino, Renato</creatorcontrib><creatorcontrib>Massoud, Michela</creatorcontrib><creatorcontrib>Gabriella Mazzucconi, Maria</creatorcontrib><creatorcontrib>Milan, Marta</creatorcontrib><creatorcontrib>Morfini, Massimo</creatorcontrib><creatorcontrib>Napolitano, Mariasanta</creatorcontrib><creatorcontrib>Pasca, Samantha</creatorcontrib><creatorcontrib>Pedrazzi, Paola</creatorcontrib><creatorcontrib>Peyvandi, Flora A.</creatorcontrib><creatorcontrib>Piscitelli, Lydia</creatorcontrib><creatorcontrib>Pollio, Berardino</creatorcontrib><creatorcontrib>Preti, Paola</creatorcontrib><creatorcontrib>Quintavalle, Gabriele</creatorcontrib><creatorcontrib>Radossi, Paolo</creatorcontrib><creatorcontrib>Raso, Simona</creatorcontrib><creatorcontrib>Ricca, Irene</creatorcontrib><creatorcontrib>Rocino, Angiola</creatorcontrib><creatorcontrib>Santoro, Cristina</creatorcontrib><creatorcontrib>Carlotta Santoro, Rita</creatorcontrib><creatorcontrib>Sarolo, Lucia</creatorcontrib><creatorcontrib>Schiavoni, Mario</creatorcontrib><creatorcontrib>Schiavulli, Michele</creatorcontrib><creatorcontrib>Sciancalepore, Patrizia</creatorcontrib><creatorcontrib>Luisa Serino, Maria</creatorcontrib><creatorcontrib>Mario Siragusa, Sergio</creatorcontrib><creatorcontrib>Sottilotta, Gianluca</creatorcontrib><creatorcontrib>Svahn, Johanna</creatorcontrib><creatorcontrib>Valdrè, Lelia</creatorcontrib><creatorcontrib>Cristina Vedovati, Maria</creatorcontrib><creatorcontrib>Zanon, Ezio</creatorcontrib><creatorcontrib>the HEVA Study Group</creatorcontrib><title>Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project</title><title>Haemophilia : the official journal of the World Federation of Hemophilia</title><addtitle>Haemophilia</addtitle><description>Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5‐point Likert‐type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence‐ and consensus‐based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.</description><subject>Adult</subject><subject>Bleeding</subject><subject>bleeding disorder</subject><subject>Child</subject><subject>Coagulation factor VIII</subject><subject>Coagulation factors</subject><subject>Consensus</subject><subject>Delphi Technique</subject><subject>Evidence-Based Medicine</subject><subject>factor VIII inhibitor</subject><subject>haemophilia</subject><subject>Hemophilia</subject><subject>Hemophilia A - prevention & control</subject><subject>Hemophilia B - prevention & 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Lelia</creator><creator>Cristina Vedovati, Maria</creator><creator>Zanon, Ezio</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5920-6191</orcidid></search><sort><creationdate>201907</creationdate><title>Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project</title><author>Santagostino, Elena ; Riva, Agostino ; Cesaro, Simone ; Esposito, Susanna ; Matino, Davide ; Mazzucchelli, Renata Ilde ; Molinari, Angelo Claudio ; Mura, Rosamaria ; Notarangelo, Lucia Dora ; Tagliaferri, Annarita ; Di Minno, Giovanni ; Clerici, Mario ; Ambaglio, Chiara ; Brigida Aru, Anna ; Baldacci, Erminia ; Barillari, Giovanni ; Basso, Maria ; Bernasconi, Sayla ; Bertamino, Marta ; Bertoni, Elisa ; Biasoli, Chiara ; Federica Biguzzi, Eugenia ; Bonetti, Elisa ; Borchiellini, Alessandra ; Bulgarelli, Simona ; Cabibbo, Sergio ; Cantori, Isabella ; Castaman, Giancarlo ; Castiglia, Paolo ; Coluccia, Antonella ; Coppetelli, Ugo ; Coppola, Antonio ; Cultrera, Dorina ; De Candia, Erica ; Delios, Grazia ; Di Gennaro, Leonardo ; Di Gregorio, Patrizia ; Di Minno, Matteo ; Dragani, Alfredo ; Pietro Ettorre, Cosimo ; Franchini, Massimo ; Galli, Massimo ; Gallo, Giovanni ; Giordano, Paola ; Giuffrida, Gaetano ; Iannaccaro, Piergiorgio ; Lassandro, Giuseppe ; Lazzareschi, Ilaria ; Linari, Silvia ; Luciani, Matteo ; Macchi, Silvia ; Malcangi, Giuseppe ; Malizia, Raniero ; Marietta, Marco ; Marino, Renato ; Massoud, Michela ; Gabriella Mazzucconi, Maria ; Milan, Marta ; Morfini, Massimo ; Napolitano, Mariasanta ; Pasca, Samantha ; Pedrazzi, Paola ; Peyvandi, Flora A. ; Piscitelli, Lydia ; Pollio, Berardino ; Preti, Paola ; Quintavalle, Gabriele ; Radossi, Paolo ; Raso, Simona ; Ricca, Irene ; Rocino, Angiola ; Santoro, Cristina ; Carlotta Santoro, Rita ; Sarolo, Lucia ; Schiavoni, Mario ; Schiavulli, Michele ; Sciancalepore, Patrizia ; Luisa Serino, Maria ; Mario Siragusa, Sergio ; Sottilotta, Gianluca ; Svahn, Johanna ; Valdrè, Lelia ; Cristina Vedovati, Maria ; Zanon, Ezio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-11c139ff79a05fb40998beadafd71a759c2abec219d1f689c7a1ec61e20760b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bleeding</topic><topic>bleeding disorder</topic><topic>Child</topic><topic>Coagulation factor VIII</topic><topic>Coagulation factors</topic><topic>Consensus</topic><topic>Delphi Technique</topic><topic>Evidence-Based Medicine</topic><topic>factor VIII inhibitor</topic><topic>haemophilia</topic><topic>Hemophilia</topic><topic>Hemophilia A - prevention & control</topic><topic>Hemophilia B - prevention & control</topic><topic>Humans</topic><topic>Immunization</topic><topic>Italy</topic><topic>Original</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santagostino, Elena</creatorcontrib><creatorcontrib>Riva, Agostino</creatorcontrib><creatorcontrib>Cesaro, Simone</creatorcontrib><creatorcontrib>Esposito, Susanna</creatorcontrib><creatorcontrib>Matino, Davide</creatorcontrib><creatorcontrib>Mazzucchelli, Renata Ilde</creatorcontrib><creatorcontrib>Molinari, Angelo Claudio</creatorcontrib><creatorcontrib>Mura, Rosamaria</creatorcontrib><creatorcontrib>Notarangelo, Lucia Dora</creatorcontrib><creatorcontrib>Tagliaferri, Annarita</creatorcontrib><creatorcontrib>Di Minno, Giovanni</creatorcontrib><creatorcontrib>Clerici, Mario</creatorcontrib><creatorcontrib>Ambaglio, Chiara</creatorcontrib><creatorcontrib>Brigida Aru, Anna</creatorcontrib><creatorcontrib>Baldacci, Erminia</creatorcontrib><creatorcontrib>Barillari, Giovanni</creatorcontrib><creatorcontrib>Basso, Maria</creatorcontrib><creatorcontrib>Bernasconi, Sayla</creatorcontrib><creatorcontrib>Bertamino, Marta</creatorcontrib><creatorcontrib>Bertoni, Elisa</creatorcontrib><creatorcontrib>Biasoli, Chiara</creatorcontrib><creatorcontrib>Federica Biguzzi, Eugenia</creatorcontrib><creatorcontrib>Bonetti, Elisa</creatorcontrib><creatorcontrib>Borchiellini, Alessandra</creatorcontrib><creatorcontrib>Bulgarelli, Simona</creatorcontrib><creatorcontrib>Cabibbo, Sergio</creatorcontrib><creatorcontrib>Cantori, Isabella</creatorcontrib><creatorcontrib>Castaman, Giancarlo</creatorcontrib><creatorcontrib>Castiglia, Paolo</creatorcontrib><creatorcontrib>Coluccia, Antonella</creatorcontrib><creatorcontrib>Coppetelli, Ugo</creatorcontrib><creatorcontrib>Coppola, Antonio</creatorcontrib><creatorcontrib>Cultrera, Dorina</creatorcontrib><creatorcontrib>De Candia, Erica</creatorcontrib><creatorcontrib>Delios, Grazia</creatorcontrib><creatorcontrib>Di Gennaro, Leonardo</creatorcontrib><creatorcontrib>Di Gregorio, Patrizia</creatorcontrib><creatorcontrib>Di Minno, Matteo</creatorcontrib><creatorcontrib>Dragani, Alfredo</creatorcontrib><creatorcontrib>Pietro Ettorre, Cosimo</creatorcontrib><creatorcontrib>Franchini, Massimo</creatorcontrib><creatorcontrib>Galli, Massimo</creatorcontrib><creatorcontrib>Gallo, Giovanni</creatorcontrib><creatorcontrib>Giordano, Paola</creatorcontrib><creatorcontrib>Giuffrida, Gaetano</creatorcontrib><creatorcontrib>Iannaccaro, Piergiorgio</creatorcontrib><creatorcontrib>Lassandro, Giuseppe</creatorcontrib><creatorcontrib>Lazzareschi, Ilaria</creatorcontrib><creatorcontrib>Linari, Silvia</creatorcontrib><creatorcontrib>Luciani, Matteo</creatorcontrib><creatorcontrib>Macchi, Silvia</creatorcontrib><creatorcontrib>Malcangi, Giuseppe</creatorcontrib><creatorcontrib>Malizia, Raniero</creatorcontrib><creatorcontrib>Marietta, Marco</creatorcontrib><creatorcontrib>Marino, Renato</creatorcontrib><creatorcontrib>Massoud, Michela</creatorcontrib><creatorcontrib>Gabriella Mazzucconi, Maria</creatorcontrib><creatorcontrib>Milan, Marta</creatorcontrib><creatorcontrib>Morfini, Massimo</creatorcontrib><creatorcontrib>Napolitano, Mariasanta</creatorcontrib><creatorcontrib>Pasca, Samantha</creatorcontrib><creatorcontrib>Pedrazzi, Paola</creatorcontrib><creatorcontrib>Peyvandi, Flora A.</creatorcontrib><creatorcontrib>Piscitelli, Lydia</creatorcontrib><creatorcontrib>Pollio, Berardino</creatorcontrib><creatorcontrib>Preti, Paola</creatorcontrib><creatorcontrib>Quintavalle, Gabriele</creatorcontrib><creatorcontrib>Radossi, Paolo</creatorcontrib><creatorcontrib>Raso, Simona</creatorcontrib><creatorcontrib>Ricca, Irene</creatorcontrib><creatorcontrib>Rocino, Angiola</creatorcontrib><creatorcontrib>Santoro, Cristina</creatorcontrib><creatorcontrib>Carlotta Santoro, Rita</creatorcontrib><creatorcontrib>Sarolo, Lucia</creatorcontrib><creatorcontrib>Schiavoni, Mario</creatorcontrib><creatorcontrib>Schiavulli, Michele</creatorcontrib><creatorcontrib>Sciancalepore, Patrizia</creatorcontrib><creatorcontrib>Luisa Serino, Maria</creatorcontrib><creatorcontrib>Mario Siragusa, Sergio</creatorcontrib><creatorcontrib>Sottilotta, Gianluca</creatorcontrib><creatorcontrib>Svahn, Johanna</creatorcontrib><creatorcontrib>Valdrè, Lelia</creatorcontrib><creatorcontrib>Cristina Vedovati, Maria</creatorcontrib><creatorcontrib>Zanon, Ezio</creatorcontrib><creatorcontrib>the HEVA Study Group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Haemophilia : the official journal of the World Federation of Hemophilia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santagostino, Elena</au><au>Riva, Agostino</au><au>Cesaro, Simone</au><au>Esposito, Susanna</au><au>Matino, Davide</au><au>Mazzucchelli, Renata Ilde</au><au>Molinari, Angelo Claudio</au><au>Mura, Rosamaria</au><au>Notarangelo, Lucia Dora</au><au>Tagliaferri, Annarita</au><au>Di Minno, Giovanni</au><au>Clerici, Mario</au><au>Ambaglio, Chiara</au><au>Brigida Aru, Anna</au><au>Baldacci, Erminia</au><au>Barillari, Giovanni</au><au>Basso, Maria</au><au>Bernasconi, Sayla</au><au>Bertamino, Marta</au><au>Bertoni, Elisa</au><au>Biasoli, Chiara</au><au>Federica Biguzzi, Eugenia</au><au>Bonetti, Elisa</au><au>Borchiellini, Alessandra</au><au>Bulgarelli, Simona</au><au>Cabibbo, Sergio</au><au>Cantori, Isabella</au><au>Castaman, Giancarlo</au><au>Castiglia, Paolo</au><au>Coluccia, Antonella</au><au>Coppetelli, Ugo</au><au>Coppola, Antonio</au><au>Cultrera, Dorina</au><au>De Candia, Erica</au><au>Delios, Grazia</au><au>Di Gennaro, Leonardo</au><au>Di Gregorio, Patrizia</au><au>Di Minno, Matteo</au><au>Dragani, Alfredo</au><au>Pietro Ettorre, Cosimo</au><au>Franchini, Massimo</au><au>Galli, Massimo</au><au>Gallo, Giovanni</au><au>Giordano, Paola</au><au>Giuffrida, Gaetano</au><au>Iannaccaro, Piergiorgio</au><au>Lassandro, Giuseppe</au><au>Lazzareschi, Ilaria</au><au>Linari, Silvia</au><au>Luciani, Matteo</au><au>Macchi, Silvia</au><au>Malcangi, Giuseppe</au><au>Malizia, Raniero</au><au>Marietta, Marco</au><au>Marino, Renato</au><au>Massoud, Michela</au><au>Gabriella Mazzucconi, Maria</au><au>Milan, Marta</au><au>Morfini, Massimo</au><au>Napolitano, Mariasanta</au><au>Pasca, Samantha</au><au>Pedrazzi, Paola</au><au>Peyvandi, Flora A.</au><au>Piscitelli, Lydia</au><au>Pollio, Berardino</au><au>Preti, Paola</au><au>Quintavalle, Gabriele</au><au>Radossi, Paolo</au><au>Raso, Simona</au><au>Ricca, Irene</au><au>Rocino, Angiola</au><au>Santoro, Cristina</au><au>Carlotta Santoro, Rita</au><au>Sarolo, Lucia</au><au>Schiavoni, Mario</au><au>Schiavulli, Michele</au><au>Sciancalepore, Patrizia</au><au>Luisa Serino, Maria</au><au>Mario Siragusa, Sergio</au><au>Sottilotta, Gianluca</au><au>Svahn, Johanna</au><au>Valdrè, Lelia</au><au>Cristina Vedovati, Maria</au><au>Zanon, Ezio</au><aucorp>the HEVA Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project</atitle><jtitle>Haemophilia : the official journal of the World Federation of Hemophilia</jtitle><addtitle>Haemophilia</addtitle><date>2019-07</date><risdate>2019</risdate><volume>25</volume><issue>4</issue><spage>656</spage><epage>667</epage><pages>656-667</pages><issn>1351-8216</issn><issn>1365-2516</issn><eissn>1365-2516</eissn><abstract>Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5‐point Likert‐type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence‐ and consensus‐based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30990961</pmid><doi>10.1111/hae.13756</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5920-6191</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-8216 |
| ispartof | Haemophilia : the official journal of the World Federation of Hemophilia, 2019-07, Vol.25 (4), p.656-667 |
| issn | 1351-8216 1365-2516 1365-2516 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6850056 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Bleeding bleeding disorder Child Coagulation factor VIII Coagulation factors Consensus Delphi Technique Evidence-Based Medicine factor VIII inhibitor haemophilia Hemophilia Hemophilia A - prevention & control Hemophilia B - prevention & control Humans Immunization Italy Original Vaccination Vaccines |
| title | Consensus statements on vaccination in patients with haemophilia—Results from the Italian haemophilia and vaccinations (HEVA) project |
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