Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas

While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune responses affect glioblastoma (GBM) growth and treatment resistance. However, the impact of the major immune cell population in gliomas, repres...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2019-07, Vol.29 (4), p.513-529
Hauptverfasser:	Zeiner, Pia S., Preusse, Corinna, Golebiewska, Anna, Zinke, Jenny, Iriondo, Ane, Muller, Arnaud, Kaoma, Tony, Filipski, Katharina, Müller‐Eschner, Monika, Bernatz, Simon, Blank, Anna‐Eva, Baumgarten, Peter, Ilina, Elena, Grote, Anne, Hansmann, Martin L., Verhoff, Marcel A., Franz, Kea, Feuerhake, Friedrich, Steinbach, Joachim P., Wischhusen, Jörg, Stenzel, Werner, Niclou, Simone P., Harter, Patrick N., Mittelbronn, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adult Aged Animals Astrocytoma Astrocytoma - pathology Brain Brain cancer Brain Neoplasms - pathology Brain tumors Carbon tetrachloride CD11b antigen CD163 antigen Cell Line, Tumor Central nervous system Female Gene expression Glioblastoma Glioblastoma - pathology Glioma Glioma - immunology Glioma - metabolism Glioma - pathology glioma‐associated microglia and macrophages Humans immune polarization Immune response Immune system Immunocytochemistry Immunohistochemistry Impact resistance Inflammation Interleukin 1 Interleukin 10 Macrophages Macrophages - immunology Macrophages - pathology Male Markers Mice Microglia Microglia - immunology Microglia - pathology Middle Aged Monocyte chemoattractant protein 1 Patients Phagocytes Prognosis Survival Treatment resistance Tumor Microenvironment Tumors Xenograft Model Antitumor Assays
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