Urate‐lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis

Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and cardiovascular disease. However, the role of soluble serum urate (SU) on atherosclerosis development remains elusive. We aimed to use a new HU mouse model [Uricase/Uox knockout (KO)] to further investigate the relatio...

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Veröffentlicht in:	The FEBS journal 2019-04, Vol.286 (7), p.1346-1359
Hauptverfasser:	Lu, Jie, Sun, Mingshu, Wu, Xinjiang, Yuan, Xuan, Liu, Zhen, Qu, Xiaojie, Ji, Xiaopeng, Merriman, Tony R., Li, Changgui
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol Allopurinol - pharmacology animal model Animals Antimetabolites - pharmacology Antioxidants Arteriosclerosis Atherosclerosis Cardiovascular diseases Carotid Artery Diseases - etiology Carotid Artery Diseases - pathology Carotid Artery Diseases - prevention & control Endothelial cells Gout Histology Human Umbilical Vein Endothelial Cells Humans Hyperuricemia Hyperuricemia - complications Hyperuricemia - physiopathology Inflammation Inflammation - etiology Inflammation - pathology Inflammation - prevention & control Inflammatory response Lesions Male Mice Mice, Inbred C57BL Mice, Knockout Neointima - etiology Neointima - pathology Neointima - prevention & control Original Placement Proliferating cell nuclear antigen Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Therapy Umbilical vein urate Urate oxidase Urate Oxidase - physiology Uric acid Uric Acid - metabolism
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