Mechanistic studies of a "Declick" reaction

A kinetic analysis of a "declick" reaction is described. Compound 1 , previously reported to couple an amine and a thiol ( i.e. "click") under mild aqueous conditions to create 2 , undergoes release of the unaltered coupling partners upon triggering with dithiothreitol ( DTT ). I...

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Veröffentlicht in:	Chemical science (Cambridge) 2019-10, Vol.1 (38), p.8817-8824
Hauptverfasser:	Meadows, Margaret K, Sun, Xiaolong, Kolesnichenko, Igor V, Hinson, Caroline M, Johnson, Kenneth A, Anslyn, Eric V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Aniline Chemistry Expulsion INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Numerical integration Rate constants Reaction kinetics Singular value decomposition Spectra Spectrum analysis Thiols Time dependence
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