Somatic mutations precede acute myeloid leukemia years before diagnosis

The pattern of somatic mutations observed at diagnosis of acute myeloid leukemia (AML) has been well-characterized. However, the premalignant mutational landscape of AML and its impact on risk and time to diagnosis is unknown. Here we identified 212 women from the Women’s Health Initiative who were...

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Veröffentlicht in:	Nature medicine 2018-07, Vol.24 (7), p.1015-1023
Hauptverfasser:	Desai, Pinkal, Mencia-Trinchant, Nuria, Savenkov, Oleksandr, Simon, Michael S., Cheang, Gloria, Lee, Sangmin, Samuel, Michael, Ritchie, Ellen K., Guzman, Monica L., Ballman, Karla V., Roboz, Gail J., Hassane, Duane C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/1897 631/67/69 692/699/67/2324 Acute myelocytic leukemia Acute myeloid leukemia Alleles Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Clonal Evolution Deoxyribonucleic acid Diagnosis Disease Progression DNA DNA sequencing Female Gene mutation Genes Genetic aspects Health Health promotion Humans Infectious Diseases Latency Leukemia Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Metabolic Diseases Methyltransferases Molecular Medicine Multivariate Analysis Mutation Mutation - genetics Mutation Rate Myeloid leukemia Neurosciences Odds Ratio p53 Protein Patients Peripheral blood Risk Factors Tumor proteins Women Women's health
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