Aspartate Residues Far from the Active Site Drive O‑GlcNAc Transferase Substrate Selection

O-GlcNAc is an abundant post-translational modification found on nuclear and cytoplasmic proteins in all metazoans. This modification regulates a wide variety of cellular processes, and elevated O-GlcNAc levels have been implicated in cancer progression. A single essential enzyme, O-GlcNAc transfera...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2019-08, Vol.141 (33), p.12974-12978
Hauptverfasser:	Joiner, Cassandra M, Levine, Zebulon G, Aonbangkhen, Chanat, Woo, Christina M, Walker, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence Animalia aspartic acid Aspartic Acid - analysis Aspartic Acid - metabolism Catalytic Domain enzyme substrates Glycosylation Humans Models, Molecular N-Acetylglucosaminyltransferases - chemistry N-Acetylglucosaminyltransferases - metabolism neoplasm progression neoplasms protein microarrays proteins Substrate Specificity Tetratricopeptide Repeat transferases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!