Inhibition of COX‐2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture

ABSTRACT Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around a synovial joint leading to debilitating loss of motion. Treatment options are limited because the pathologic mechanisms remain to be...

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Veröffentlicht in:	Journal of orthopaedic research 2019-12, Vol.37 (12), p.2609-2620
Hauptverfasser:	Salib, Christopher G., Reina, Nicolas, Trousdale, William H., Limberg, Afton K., Tibbo, Megan E., Jay, Anthony G., Robin, Joseph X., Turner, Travis W., Jones, Carter R., Paradise, Christopher R., Lewallen, Eric A., Bolon, Brad, Carter, Jodi M., Berry, Daniel J., Morrey, Mark E., Sanchez‐Sotelo, Joaquin, Wijnen, Andre J., Abdel, Matthew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arthrofibrosis Arthroplasty, Replacement, Knee - adverse effects Biomechanical Phenomena celecoxib Celecoxib - pharmacology Collagen - metabolism Contracture - prevention & control COX‐2 inhibition Cyclooxygenase 2 Inhibitors - pharmacology Disease Models, Animal Female Fibrosis Joints - pathology myofibroblast Myofibroblasts - physiology Rabbits total knee arthroplasty
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