Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial

Background General medical hospitals provide care for a disproportionate share of patients who misuse substances. Hospitalization provides a unique opportunity to identify and motivate patients to address their substance misuse. Objective To determine the effectiveness of three strategies for implem...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of general internal medicine : JGIM 2019-11, Vol.34 (11), p.2520-2529
Hauptverfasser: Martino, Steve, Zimbrean, Paula, Forray, Ariadna, Kaufman, Joy S., Desan, Paul H., Olmstead, Todd A., Gilstad-Hayden, Kathryn, Gueorguieva, Ralitza, Yonkers, Kimberly A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2529
container_issue 11
container_start_page 2520
container_title Journal of general internal medicine : JGIM
container_volume 34
creator Martino, Steve
Zimbrean, Paula
Forray, Ariadna
Kaufman, Joy S.
Desan, Paul H.
Olmstead, Todd A.
Gilstad-Hayden, Kathryn
Gueorguieva, Ralitza
Yonkers, Kimberly A.
description Background General medical hospitals provide care for a disproportionate share of patients who misuse substances. Hospitalization provides a unique opportunity to identify and motivate patients to address their substance misuse. Objective To determine the effectiveness of three strategies for implementing motivational interviewing for substance misuse with general medical inpatients. Design Type 3 hybrid effectiveness-implementation randomized controlled trial (Clinical Trials.gov : NCT01825057). Participants Thirty-eight providers (physicians, physician assistants, nurses) from 13 general medical inpatient services, and 1173 of their patients admitted to an academically affiliated acute care hospital. Interventions Implementation strategies included (1) a continuing medical education workshop on detection of substance misuse and provision of a motivational interview; (2) workshop plus bedside supervision (apprenticeship condition); and (3) a workshop plus ability to place a medical order for an interview from a consultation-liaison service (consult condition). Main Measures Primary outcomes were the percentage of study-eligible patients who received an interview for substance misuse and the integrity (adherence, competence) of the interviews. The secondary outcome was the percent of patient statements within the interviews that indicated motivation for reducing substance misuse. Key Results 20.5% of patients in the consult condition received an interview, compared to 0.8% (Hedge’s g  = 1.49) and 3.0% (Hedge’s g  = 1.26) in the respective workshop only and apprenticeship conditions ( p  
doi_str_mv 10.1007/s11606-019-05257-3
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6848470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2283107201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-48e82e557879946db3920f21fb7bcebd6731afda9442f904eb1ff6d90309e74d3</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhi0EoiHwBzggS1y4LPgra5sDUhWVNlIjJGjPlnc9G1zt2sHeDWp_fZ2klI8DJ480z7yeeV-EXlPynhIiP2RKa1JXhOqKLNhCVvwJmtFSVVRo-RTNiFKiUpKLE_Qi5xtCKGdMPUcnnIpaccFmaFoN2x4GCKMPG7yOo9_Z0cdge7wKI6Sdh5_7ThcT_jY1ebShBbz2ecqAY8BrcL49wNsyV2TwdfBj_ogt_mqDi4O_A4eXMYwp9n0pr5K3_Uv0rLN9hlcP7xxdfz67Wl5Ul1_OV8vTy6oVUoyVUKAYLBZSSa1F7RquGekY7RrZtNC4WnJqO2e1EKzTREBDu652mnCiQQrH5-jTUXc7NQO4tuyXbG-2yQ823Zpovfm7E_x3s4k7UyuhhCRF4N2DQIo_JsijGXxuoe9tgDhlU-zklEhWnJ2jt_-gN3FKxcgDxTjlst5T7Ei1KeacoHtchhKzT9UcUzUlVXNI1fAy9ObPMx5HfsVYAH4EcmmFDaTff_9H9h50Na-f</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2282313761</pqid></control><display><type>article</type><title>Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial</title><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Martino, Steve ; Zimbrean, Paula ; Forray, Ariadna ; Kaufman, Joy S. ; Desan, Paul H. ; Olmstead, Todd A. ; Gilstad-Hayden, Kathryn ; Gueorguieva, Ralitza ; Yonkers, Kimberly A.</creator><creatorcontrib>Martino, Steve ; Zimbrean, Paula ; Forray, Ariadna ; Kaufman, Joy S. ; Desan, Paul H. ; Olmstead, Todd A. ; Gilstad-Hayden, Kathryn ; Gueorguieva, Ralitza ; Yonkers, Kimberly A.</creatorcontrib><description>Background General medical hospitals provide care for a disproportionate share of patients who misuse substances. Hospitalization provides a unique opportunity to identify and motivate patients to address their substance misuse. Objective To determine the effectiveness of three strategies for implementing motivational interviewing for substance misuse with general medical inpatients. Design Type 3 hybrid effectiveness-implementation randomized controlled trial (Clinical Trials.gov : NCT01825057). Participants Thirty-eight providers (physicians, physician assistants, nurses) from 13 general medical inpatient services, and 1173 of their patients admitted to an academically affiliated acute care hospital. Interventions Implementation strategies included (1) a continuing medical education workshop on detection of substance misuse and provision of a motivational interview; (2) workshop plus bedside supervision (apprenticeship condition); and (3) a workshop plus ability to place a medical order for an interview from a consultation-liaison service (consult condition). Main Measures Primary outcomes were the percentage of study-eligible patients who received an interview for substance misuse and the integrity (adherence, competence) of the interviews. The secondary outcome was the percent of patient statements within the interviews that indicated motivation for reducing substance misuse. Key Results 20.5% of patients in the consult condition received an interview, compared to 0.8% (Hedge’s g  = 1.49) and 3.0% (Hedge’s g  = 1.26) in the respective workshop only and apprenticeship conditions ( p  &lt; 0.001). Motivational interviews in the consult condition were performed with more fundamental motivational interviewing adherence and competence than the other conditions. Most statements made by patients during the interviews favored reducing substance misuse, with no differences between conditions. Conclusions Providers’ ability to place an order to have experts from the consultation-liaison service deliver a motivational interview was a more effective implementation strategy than a workshop or apprenticeship method for ensuring motivational interviewing is available to medical inpatients who misuse substances. Trial Registry NCT01825057</description><identifier>ISSN: 0884-8734</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-019-05257-3</identifier><identifier>PMID: 31468342</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apprenticeship ; Clinical trials ; Consultation ; Internal Medicine ; Interviews ; Medical personnel ; Medicine ; Medicine &amp; Public Health ; Motivation ; Original Research ; Patients ; Physicians ; Randomization ; Substance use disorder</subject><ispartof>Journal of general internal medicine : JGIM, 2019-11, Vol.34 (11), p.2520-2529</ispartof><rights>Society of General Internal Medicine (This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply) 2019</rights><rights>Journal of General Internal Medicine is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-48e82e557879946db3920f21fb7bcebd6731afda9442f904eb1ff6d90309e74d3</citedby><cites>FETCH-LOGICAL-c474t-48e82e557879946db3920f21fb7bcebd6731afda9442f904eb1ff6d90309e74d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848470/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848470/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31468342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martino, Steve</creatorcontrib><creatorcontrib>Zimbrean, Paula</creatorcontrib><creatorcontrib>Forray, Ariadna</creatorcontrib><creatorcontrib>Kaufman, Joy S.</creatorcontrib><creatorcontrib>Desan, Paul H.</creatorcontrib><creatorcontrib>Olmstead, Todd A.</creatorcontrib><creatorcontrib>Gilstad-Hayden, Kathryn</creatorcontrib><creatorcontrib>Gueorguieva, Ralitza</creatorcontrib><creatorcontrib>Yonkers, Kimberly A.</creatorcontrib><title>Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial</title><title>Journal of general internal medicine : JGIM</title><addtitle>J GEN INTERN MED</addtitle><addtitle>J Gen Intern Med</addtitle><description>Background General medical hospitals provide care for a disproportionate share of patients who misuse substances. Hospitalization provides a unique opportunity to identify and motivate patients to address their substance misuse. Objective To determine the effectiveness of three strategies for implementing motivational interviewing for substance misuse with general medical inpatients. Design Type 3 hybrid effectiveness-implementation randomized controlled trial (Clinical Trials.gov : NCT01825057). Participants Thirty-eight providers (physicians, physician assistants, nurses) from 13 general medical inpatient services, and 1173 of their patients admitted to an academically affiliated acute care hospital. Interventions Implementation strategies included (1) a continuing medical education workshop on detection of substance misuse and provision of a motivational interview; (2) workshop plus bedside supervision (apprenticeship condition); and (3) a workshop plus ability to place a medical order for an interview from a consultation-liaison service (consult condition). Main Measures Primary outcomes were the percentage of study-eligible patients who received an interview for substance misuse and the integrity (adherence, competence) of the interviews. The secondary outcome was the percent of patient statements within the interviews that indicated motivation for reducing substance misuse. Key Results 20.5% of patients in the consult condition received an interview, compared to 0.8% (Hedge’s g  = 1.49) and 3.0% (Hedge’s g  = 1.26) in the respective workshop only and apprenticeship conditions ( p  &lt; 0.001). Motivational interviews in the consult condition were performed with more fundamental motivational interviewing adherence and competence than the other conditions. Most statements made by patients during the interviews favored reducing substance misuse, with no differences between conditions. Conclusions Providers’ ability to place an order to have experts from the consultation-liaison service deliver a motivational interview was a more effective implementation strategy than a workshop or apprenticeship method for ensuring motivational interviewing is available to medical inpatients who misuse substances. Trial Registry NCT01825057</description><subject>Apprenticeship</subject><subject>Clinical trials</subject><subject>Consultation</subject><subject>Internal Medicine</subject><subject>Interviews</subject><subject>Medical personnel</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Motivation</subject><subject>Original Research</subject><subject>Patients</subject><subject>Physicians</subject><subject>Randomization</subject><subject>Substance use disorder</subject><issn>0884-8734</issn><issn>1525-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1vEzEQhi0EoiHwBzggS1y4LPgra5sDUhWVNlIjJGjPlnc9G1zt2sHeDWp_fZ2klI8DJ480z7yeeV-EXlPynhIiP2RKa1JXhOqKLNhCVvwJmtFSVVRo-RTNiFKiUpKLE_Qi5xtCKGdMPUcnnIpaccFmaFoN2x4GCKMPG7yOo9_Z0cdge7wKI6Sdh5_7ThcT_jY1ebShBbz2ecqAY8BrcL49wNsyV2TwdfBj_ogt_mqDi4O_A4eXMYwp9n0pr5K3_Uv0rLN9hlcP7xxdfz67Wl5Ul1_OV8vTy6oVUoyVUKAYLBZSSa1F7RquGekY7RrZtNC4WnJqO2e1EKzTREBDu652mnCiQQrH5-jTUXc7NQO4tuyXbG-2yQ823Zpovfm7E_x3s4k7UyuhhCRF4N2DQIo_JsijGXxuoe9tgDhlU-zklEhWnJ2jt_-gN3FKxcgDxTjlst5T7Ei1KeacoHtchhKzT9UcUzUlVXNI1fAy9ObPMx5HfsVYAH4EcmmFDaTff_9H9h50Na-f</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Martino, Steve</creator><creator>Zimbrean, Paula</creator><creator>Forray, Ariadna</creator><creator>Kaufman, Joy S.</creator><creator>Desan, Paul H.</creator><creator>Olmstead, Todd A.</creator><creator>Gilstad-Hayden, Kathryn</creator><creator>Gueorguieva, Ralitza</creator><creator>Yonkers, Kimberly A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191101</creationdate><title>Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial</title><author>Martino, Steve ; Zimbrean, Paula ; Forray, Ariadna ; Kaufman, Joy S. ; Desan, Paul H. ; Olmstead, Todd A. ; Gilstad-Hayden, Kathryn ; Gueorguieva, Ralitza ; Yonkers, Kimberly A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-48e82e557879946db3920f21fb7bcebd6731afda9442f904eb1ff6d90309e74d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apprenticeship</topic><topic>Clinical trials</topic><topic>Consultation</topic><topic>Internal Medicine</topic><topic>Interviews</topic><topic>Medical personnel</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Motivation</topic><topic>Original Research</topic><topic>Patients</topic><topic>Physicians</topic><topic>Randomization</topic><topic>Substance use disorder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martino, Steve</creatorcontrib><creatorcontrib>Zimbrean, Paula</creatorcontrib><creatorcontrib>Forray, Ariadna</creatorcontrib><creatorcontrib>Kaufman, Joy S.</creatorcontrib><creatorcontrib>Desan, Paul H.</creatorcontrib><creatorcontrib>Olmstead, Todd A.</creatorcontrib><creatorcontrib>Gilstad-Hayden, Kathryn</creatorcontrib><creatorcontrib>Gueorguieva, Ralitza</creatorcontrib><creatorcontrib>Yonkers, Kimberly A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of general internal medicine : JGIM</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martino, Steve</au><au>Zimbrean, Paula</au><au>Forray, Ariadna</au><au>Kaufman, Joy S.</au><au>Desan, Paul H.</au><au>Olmstead, Todd A.</au><au>Gilstad-Hayden, Kathryn</au><au>Gueorguieva, Ralitza</au><au>Yonkers, Kimberly A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial</atitle><jtitle>Journal of general internal medicine : JGIM</jtitle><stitle>J GEN INTERN MED</stitle><addtitle>J Gen Intern Med</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>34</volume><issue>11</issue><spage>2520</spage><epage>2529</epage><pages>2520-2529</pages><issn>0884-8734</issn><eissn>1525-1497</eissn><abstract>Background General medical hospitals provide care for a disproportionate share of patients who misuse substances. Hospitalization provides a unique opportunity to identify and motivate patients to address their substance misuse. Objective To determine the effectiveness of three strategies for implementing motivational interviewing for substance misuse with general medical inpatients. Design Type 3 hybrid effectiveness-implementation randomized controlled trial (Clinical Trials.gov : NCT01825057). Participants Thirty-eight providers (physicians, physician assistants, nurses) from 13 general medical inpatient services, and 1173 of their patients admitted to an academically affiliated acute care hospital. Interventions Implementation strategies included (1) a continuing medical education workshop on detection of substance misuse and provision of a motivational interview; (2) workshop plus bedside supervision (apprenticeship condition); and (3) a workshop plus ability to place a medical order for an interview from a consultation-liaison service (consult condition). Main Measures Primary outcomes were the percentage of study-eligible patients who received an interview for substance misuse and the integrity (adherence, competence) of the interviews. The secondary outcome was the percent of patient statements within the interviews that indicated motivation for reducing substance misuse. Key Results 20.5% of patients in the consult condition received an interview, compared to 0.8% (Hedge’s g  = 1.49) and 3.0% (Hedge’s g  = 1.26) in the respective workshop only and apprenticeship conditions ( p  &lt; 0.001). Motivational interviews in the consult condition were performed with more fundamental motivational interviewing adherence and competence than the other conditions. Most statements made by patients during the interviews favored reducing substance misuse, with no differences between conditions. Conclusions Providers’ ability to place an order to have experts from the consultation-liaison service deliver a motivational interview was a more effective implementation strategy than a workshop or apprenticeship method for ensuring motivational interviewing is available to medical inpatients who misuse substances. Trial Registry NCT01825057</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31468342</pmid><doi>10.1007/s11606-019-05257-3</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0884-8734
ispartof Journal of general internal medicine : JGIM, 2019-11, Vol.34 (11), p.2520-2529
issn 0884-8734
1525-1497
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6848470
source SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection
subjects Apprenticeship
Clinical trials
Consultation
Internal Medicine
Interviews
Medical personnel
Medicine
Medicine & Public Health
Motivation
Original Research
Patients
Physicians
Randomization
Substance use disorder
title Implementing Motivational Interviewing for Substance Misuse on Medical Inpatient Units: a Randomized Controlled Trial
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A05%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Implementing%20Motivational%20Interviewing%20for%20Substance%20Misuse%20on%20Medical%20Inpatient%20Units:%20a%20Randomized%20Controlled%20Trial&rft.jtitle=Journal%20of%20general%20internal%20medicine%20:%20JGIM&rft.au=Martino,%20Steve&rft.date=2019-11-01&rft.volume=34&rft.issue=11&rft.spage=2520&rft.epage=2529&rft.pages=2520-2529&rft.issn=0884-8734&rft.eissn=1525-1497&rft_id=info:doi/10.1007/s11606-019-05257-3&rft_dat=%3Cproquest_pubme%3E2283107201%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2282313761&rft_id=info:pmid/31468342&rfr_iscdi=true