Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice

Chemotherapy treatment negatively affects the nervous and immune systems and alters gastrointestinal function and microbial composition. Outside of the cancer field, alterations in commensal bacteria and immune function have been implicated in behavioral deficits; however, the extent to which intest...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16490-16, Article 16490
Hauptverfasser:	Loman, B. R., Jordan, K. R., Haynes, B., Bailey, M. T., Pyter, L. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/51 14 14/63 38 38/23 38/77 59 631/443/376 64 64/60 692/308/575 82 82/80 Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bacteria Bacteria - drug effects Biomarkers Brain - drug effects Brain - metabolism Brain - pathology Chemokines Chemotherapy Cognitive ability Cognitive Dysfunction - etiology Colon Colon - drug effects Colon - metabolism Colon - pathology Community composition Community structure Cytokines - blood Cytokines - genetics Cytokines - metabolism Dentate gyrus Digestive system Disease Models, Animal Dysbiosis - etiology Fatigue Fatigue - etiology Female Gastrointestinal Microbiome - drug effects Gastrointestinal tract Gene expression Gene Expression Regulation - drug effects Histology Homeostasis Homeostasis - drug effects Humanities and Social Sciences IL-1β Illness Behavior Immune response Immune System - drug effects Immunoreactivity Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation Mediators - blood Inflammation Mediators - metabolism Interleukin 6 Intestinal microflora Intestine Mice Microbiomes Microbiota Microglia multidisciplinary Paclitaxel Prefrontal cortex Science Science (multidisciplinary) Spleen
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