GENE-34. THERAPEUTICALLY TARGETING EPIGENOMIC AND TRANSCRIPTIONAL DYSFUNCTION IN ATRX-DEFICIENT GLIOMA

Abstract Diffusely infiltrating gliomas feature loss-of-function mutations in the chromatin remodeler gene ATRX as defining molecular alterations delineating major adult and pediatric disease subtypes. We recently reported that Atrx deficiency drives glioma-relevant phenotypes, such as increased mot...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2019-11, Vol.21 (Supplement_6), p.vi104-vi105
Hauptverfasser:	Danussi, Carla, Singh, Anand, Pinnamaneni, Pavan, Fisher, Grant, Picketts, David, Kannan, Kasthuri, Rao, Arvind, Rai, Kunal, Huse, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetics and Epigenetics
Online-Zugang:	Volltext
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