A general LC-MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures

Abstract A complete understanding of the structural and functional potential of RNA requires understanding of chemical modifications and non-canonical bases; this in turn requires advances in current sequencing methods to be able to sequence not only canonical ribonucleotides, but at the same time d...

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Veröffentlicht in:	Nucleic acids research 2019-11, Vol.47 (20), p.e125-e125
Hauptverfasser:	Zhang, Ning, Shi, Shundi, Jia, Tony Z, Ziegler, Ashley, Yoo, Barney, Yuan, Xiaohong, Li, Wenjia, Zhang, Shenglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Mass Spectrometry - methods Mass Spectrometry - standards Methods Online RNA - chemistry RNA - genetics RNA - metabolism RNA Processing, Post-Transcriptional Sensitivity and Specificity Sequence Analysis, RNA - methods Sequence Analysis, RNA - standards
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