Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening. All the newly synthesised compounds were evaluated in vitro for...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.72-84
Hauptverfasser:	Liu, Jian, Wen, Yu, Gao, Lina, Gao, Liang, He, Fengjun, Zhou, Jingxian, Wang, Junwei, Dai, Rupeng, Chen, Xiaojing, Kang, Di, Hu, Lihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Antifungal agents Benzothiazole FGFR1 FGFR1 inhibitor Fibroblast growth factor receptor 1 Fibroblast growth factor receptors Fragment-based virtual screening Kinases Research Paper
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!