Directed C(sp)-H arylation of tryptophan: transformation of the directing group into an activated amide

The 8-aminoquinoline (8AQ) directed C(sp 3 )-H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS) was cut short by the transformation of the direc...

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Veröffentlicht in:	Chemical science (Cambridge) 2019-10, Vol.1 (37), p.8634-8641
Hauptverfasser:	Nicke, Lennart, Horx, Philip, Harms, Klaus, Geyer, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Chain mobility Chemical synthesis Chemistry Crystallography Organic chemistry Peptides Phenylalanine Solid phases Transformations Tryptophan
Online-Zugang:	Volltext
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