Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans

Summary In Streptococcus mutans, the alternative sigma factor ComX controls entry into genetic competence. Competence stimulating peptide (CSP) induces bimodal expression of comX, with only a fraction of the population becoming transformable. Curiously, the bimodality of comX is affected by peptides...

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Veröffentlicht in:	Molecular microbiology 2019-11, Vol.112 (5), p.1388-1402
Hauptverfasser:	Underhill, Simon A. M., Shields, Robert C., Burne, Robert A., Hagen, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Carbohydrates Complex media Control theory Culture Media - chemistry DNA Transformation Competence - genetics Endopeptidases Endopeptidases - genetics Endopeptidases - metabolism Feedback Feedback loops Gene Expression Profiling Gene Expression Regulation, Bacterial Peptides Positive feedback Quorum Sensing - physiology Sigma factor Streptococcus infections Streptococcus mutans Streptococcus mutans - genetics Streptococcus mutans - growth & development Streptococcus mutans - metabolism Sugar Transcription Transcription Factors - genetics Transcription Factors - metabolism Trehalose - metabolism
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