Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions

Discovery of exosomes as modulator of cellular communication has added a new dimension to our understanding of biological processes. Exosomes influence the biological systems by mediating trans-communication across tissues and cells, which has important implication for health and disease. In absence...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16373-10, Article 16373
Hauptverfasser:	Kulshreshtha, Ankur, Singh, Swati, Ahmad, Mohd, Khanna, Kritika, Ahmad, Tanveer, Agrawal, Anurag, Ghosh, Balaram
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 13/51 14/1 14/19 631/80/313/1481 631/80/86/820 64/60 Animal models Animals Asthma - drug therapy Asthma - metabolism Atherosclerosis - drug therapy Atherosclerosis - metabolism Biosynthesis Cell interactions Cell Line Cholesterol Cholesterol - metabolism Disease Models, Animal Exosomes Exosomes - drug effects Exosomes - metabolism Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Inflammation - drug therapy Inflammation - metabolism Localization Male Mevalonic Acid - pharmacology Mice Mice, Inbred BALB C Monocytes - drug effects Monocytes - metabolism multidisciplinary Respiratory tract diseases Science Science (multidisciplinary) Secretion Simvastatin Simvastatin - pharmacology
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