Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure

Chronic wounds—including diabetic foot ulcers, venous leg ulcers, and pressure ulcers—represent a major health problem that demands an urgent solution and new therapies. Despite major burden to patients, health care professionals, and health care systems worldwide, there are no efficacious therapies...

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Veröffentlicht in:	Molecular therapy 2019-11, Vol.27 (11), p.1992-2004
Hauptverfasser:	Jozic, Ivan, Sawaya, Andrew P., Pastar, Irena, Head, Cheyanne R., Wong, Lulu L., Glinos, George D., Wikramanayake, Tongyu Cao, Brem, Harold, Kirsner, Robert S., Tomic-Canic, Marjana
Format:	Artikel
Sprache:	eng
Schlagworte:	Caveolae Caveolin Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 Cell adhesion & migration Cell growth Cell Movement Cholesterol chronic wounds CRISPR Diabetes mellitus Diabetic Foot - drug therapy Diabetic Foot - etiology Diabetic Foot - metabolism Diabetic Foot - pathology diabetic foot ulcers Epidermal growth factor Epidermal growth factor receptors Epithelium ErbB Receptors - metabolism Experiments Gene Expression Gene Expression Regulation - drug effects Glucocorticoids Glucocorticoids - pharmacology Grants Growth factors Hormones Human subjects Humans Keratinocytes - drug effects Keratinocytes - metabolism Kinases Laboratories Leg ulcers Original Patients Protein Binding Proteins Re-Epithelialization - genetics Receptors, Glucocorticoid - metabolism Signal transduction Signal Transduction - drug effects Skin - drug effects Skin - metabolism Skin - pathology skin re-epithelialization Ulcers Wound healing Wound Healing - drug effects Wound Healing - genetics
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