Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma

Melanoma is a heterogeneous tumour, but the impact of this heterogeneity upon therapeutic response is not well understood. Single cell mRNA analysis was used to define the transcriptional heterogeneity of melanoma and its dynamic response to BRAF inhibitor therapy and treatment holidays. Discrete tr...

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Veröffentlicht in:	EBioMedicine 2019-10, Vol.48, p.178-190
Hauptverfasser:	Smalley, Inna, Kim, Eunjung, Li, Jiannong, Spence, Paige, Wyatt, Clayton J., Eroglu, Zeynep, Sondak, Vernon K., Messina, Jane L., Babacan, Nalan Akgul, Maria-Engler, Silvya Stuchi, De Armas, Lesley, Williams, Sion L., Gatenby, Robert A., Chen, Y. Ann, Anderson, Alexander R.A., Smalley, Keiran S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Cell Line, Tumor Drug Resistance, Neoplasm - genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Heterogeneity Humans Mathematical modelling Melanoma Melanoma - genetics Mice MITF Models, Theoretical Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Research paper Resistance Single-Cell Analysis Transcription, Genetic Transcriptome Xenograft Model Antitumor Assays
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