Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells

Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid mainly found in fish oil. Although several studies have suggested that it can alleviate allergy symptoms, its mechanism of action remains to be elucidated. In the present study, we found that docosahexaenoyl ethanolamide (DHEA), a...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16213-11, Article 16213
Hauptverfasser:	Nishi, Kosuke, Kanayama, Yoshiki, Kim, In-Hae, Nakata, Akihiro, Nishiwaki, Hisashi, Sugahara, Takuya
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/95 64/60 692/700/2814 692/700/784 82/29 Allergies Anaphylaxis Basophilic leukemia Bone marrow Calcium - metabolism Calcium influx Cell Degranulation - drug effects Cell Line Cytokines Cytotoxicity Degranulation Docosahexaenoic acid Down-Regulation - drug effects Endocannabinoids - pharmacology Endocannabinoids - therapeutic use Fish oils Humanities and Social Sciences Hypersensitivity - drug therapy Hypersensitivity - immunology Immunoglobulin E Immunoglobulin E - immunology Intracellular Space - drug effects Intracellular Space - metabolism Leukemia Mast cells Mast Cells - cytology Mast Cells - drug effects Mast Cells - immunology Metabolites multidisciplinary Passive cutaneous anaphylaxis Pollinosis Polyunsaturated fatty acids Science Science (multidisciplinary) Signal Transduction - drug effects Signal Transduction - immunology Splenocytes
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