Differential interaction between DARC and SDF-1 on erythrocytes and their precursors

The Duffy Antigen Receptor for Chemokines (DARC) is expressed on erythrocytes and on endothelium of postcapillary venules and splenic sinusoids. Absence of DARC on erythrocytes, but not on endothelium, is referred to as the Duffy negative phenotype and is associated with neutropenia. Here we provide...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.16245-8, Article 16245
Hauptverfasser:	Klei, T. R. L., Aglialoro, F., Mul, F. P. J., Tol, S., Ligthart, P. C., Seignette, I. M., Geissler, J., van den Akker, E., van Bruggen, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 631/250/98 631/337 82 82/1 82/80 Bone marrow Chemokine CXCL12 - metabolism Chemokines Conformation Duffy antigen Duffy Blood-Group System - metabolism Endothelium Epitopes Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Humanities and Social Sciences Humans Interleukin 8 multidisciplinary Neutropenia Osteoprogenitor cells Phenotypes Protein Binding Receptors, Cell Surface - metabolism Reticulocytes - metabolism Science Science (multidisciplinary) SDF-1 protein Spleen Substrate Specificity
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