Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress
Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation o...
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| Veröffentlicht in: | Redox report : communications in free radical research 2012-09, Vol.17 (5), p.214-218 |
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| creator | Yesilova, Yavuz Turan, Enver Ucmak, Derya Selek, Sahabettin Halil Yavuz, I˙brahim Tanrıkulu, Osman |
| description | Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases. |
| doi_str_mv | 10.1179/1351000212Y.0000000025 |
| format | Article |
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The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.</description><identifier>ISSN: 1351-0002</identifier><identifier>EISSN: 1743-2928</identifier><identifier>DOI: 10.1179/1351000212Y.0000000025</identifier><identifier>PMID: 23068968</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adolescent ; Adult ; Aryldialkylphosphatase - metabolism ; Carboxylic Ester Hydrolases - metabolism ; Catalase - metabolism ; Ceruloplasmin - metabolism ; Female ; Humans ; Male ; Middle Aged ; Oxidative Stress - physiology ; Oxidative stress index ; Paraoxonase 1 ; Vitiligo ; Vitiligo - enzymology ; Vitiligo - metabolism ; Young Adult</subject><ispartof>Redox report : communications in free radical research, 2012-09, Vol.17 (5), p.214-218</ispartof><rights>W.S. Maney & Son Ltd 2012 2012</rights><rights>W.S. Maney & Son Ltd 2012 2012 W.S. 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The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aryldialkylphosphatase - metabolism</subject><subject>Carboxylic Ester Hydrolases - metabolism</subject><subject>Catalase - metabolism</subject><subject>Ceruloplasmin - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidative stress index</subject><subject>Paraoxonase 1</subject><subject>Vitiligo</subject><subject>Vitiligo - enzymology</subject><subject>Vitiligo - metabolism</subject><subject>Young Adult</subject><issn>1351-0002</issn><issn>1743-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVJabZJ_0LQMRdv9GF9uIfAEpqkECiUvfQkZGucqMjWVrKd7L-vl918nTKXGZhn3nfgReiMkiWlqrqgXFBCCKPsz5IciolPaEFVyQtWMX00zzNU7BbH6GvOf-eJy0p_QceME6krqRdo_Rvc2IDDGdLY4Y1NNj7F3mYoKA4wQcjY93jygw_-Pn7H7ZiGB0gYJu-gbwDHFscn7-zgJ8B5SJDzKfrc2pDh26GfoPX1j_XVbXH36-bn1equaErFhoIDByIAZOVYWTZVy4UoOWN1DbJWoKzTUgoBQmrrmFC25MRxrlXdKsUJP0GXe9nNWHfgGuiHZIPZJN_ZtDXRevN-0_sHcx8nIzVXshSzwPlBIMV_I-TBdD43EILtIY7ZUErZzFK985J7tEkx5wTtiw0lZpeIeZOIeU1kPjx7--TL2XMEM7DaA75vY-rsY0zBmcFuQ0xtsn3js-EfmPwH6MKb8w</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Yesilova, Yavuz</creator><creator>Turan, Enver</creator><creator>Ucmak, Derya</creator><creator>Selek, Sahabettin</creator><creator>Halil Yavuz, I˙brahim</creator><creator>Tanrıkulu, Osman</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress</title><author>Yesilova, Yavuz ; Turan, Enver ; Ucmak, Derya ; Selek, Sahabettin ; Halil Yavuz, I˙brahim ; Tanrıkulu, Osman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-3e3e05ee69d244c9f3554322bbe6b7e7ad86655e568ad257a430d3387bf77303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aryldialkylphosphatase - metabolism</topic><topic>Carboxylic Ester Hydrolases - metabolism</topic><topic>Catalase - metabolism</topic><topic>Ceruloplasmin - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidative stress index</topic><topic>Paraoxonase 1</topic><topic>Vitiligo</topic><topic>Vitiligo - enzymology</topic><topic>Vitiligo - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yesilova, Yavuz</creatorcontrib><creatorcontrib>Turan, Enver</creatorcontrib><creatorcontrib>Ucmak, Derya</creatorcontrib><creatorcontrib>Selek, Sahabettin</creatorcontrib><creatorcontrib>Halil Yavuz, I˙brahim</creatorcontrib><creatorcontrib>Tanrıkulu, Osman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Redox report : communications in free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yesilova, Yavuz</au><au>Turan, Enver</au><au>Ucmak, Derya</au><au>Selek, Sahabettin</au><au>Halil Yavuz, I˙brahim</au><au>Tanrıkulu, Osman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress</atitle><jtitle>Redox report : communications in free radical research</jtitle><addtitle>Redox Rep</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>17</volume><issue>5</issue><spage>214</spage><epage>218</epage><pages>214-218</pages><issn>1351-0002</issn><eissn>1743-2928</eissn><abstract>Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aryldialkylphosphatase - metabolism Carboxylic Ester Hydrolases - metabolism Catalase - metabolism Ceruloplasmin - metabolism Female Humans Male Middle Aged Oxidative Stress - physiology Oxidative stress index Paraoxonase 1 Vitiligo Vitiligo - enzymology Vitiligo - metabolism Young Adult |
| title | Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress |
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